Medical devices based on oxidized cellulose
View Patent ↗A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
1. A medical device comprising:
at least one of a predictably degrading coating, film, or fiber formed from an oxidized cellulose solution, the oxidized cellulose solution formed by:
contacting an oxidized cellulose with a solvent under an inert atmosphere to form a swelled oxidized cellulose;
adjusting the swelled oxidized cellulose to a first temperature in a vessel which is initially heated to the first temperature from about 115° C. to about 145° C.;
contacting the swelled oxidized cellulose with a salt under the inert atmosphere to form a modified cellulose solution; and
adjusting the modified cellulose solution to a second temperature from about 90° C. to about 120° C.
2. The medical device according to claim 1 , wherein the at least one of the fiber, the coating, or the film are formed by evaporating the solvent from the oxidized cellulose solution.
3. The medical device according to claim 2 , wherein the at least one of the fiber, the coating, or the film are formed by depositing the oxidized cellulose solution on a substrate and evaporating the solvent from the oxidized cellulose solution.
4. The medical device according to claim 1 , wherein the solvent includes N,N-Dimethylacetamide, N-methyl-2-pyrrolidinone, or combinations thereof.
5. The medical device according to claim 1 , wherein the salt includes lithium halides, sodium halides, potassium halides, or combinations thereof.
6. The medical device according to claim 1 , wherein the at least one of the fiber, the coating, or the film includes a final oxidized cellulose having a degree of oxidation from about 80% to about 120% of the degree of oxidation of the oxidized cellulose before contacting with the solvent.
7. The medical device according to claim 6 , wherein the at least one of the fiber, the coating, or the film includes a final oxidized cellulose having a molecular weight from about 80% to about 120% of the molecular weight of the oxidized cellulose before contacting with the solvent.
8. The medical device according to claim 1 , wherein the oxidized cellulose solution is contacted with at least one biocompatible plasticizer.
9. The medical device according to claim 8 , wherein the at least one biocompatible plasticizer includes lecithin, dibutyl sebacate, citric acid, polyethylene glycol, polypropylene glycol, or combinations thereof.
10. A medical device comprising:
at least one of a predictably degrading coating, film, or fiber formed from an oxidized cellulose solution, the oxidized cellulose solution formed by:
contacting an oxidized cellulose with a solvent under an inert atmosphere to form a swelled oxidized cellulose;
adjusting the swelled oxidized cellulose to a first temperature in a vessel which is initially heated to the first temperature from about 115° C. to about 145° C.;
contacting the swelled oxidized cellulose with a salt under the inert atmosphere to form a modified cellulose solution; and
adjusting the modified cellulose solution to a second temperature from about 90° C. to about 120° C.;
wherein the at least one of the coating, the film, or the fiber include a final oxidized cellulose having a degree of oxidation from about 80% to about 120% of a degree of oxidation of the oxidized cellulose before contacting with the solvent.
11. The medical device according to claim 10 , wherein the at least one of the coating, the film, or the fiber include a final oxidized cellulose having a molecular weight from about 80% to about 120% of the molecular weight of the oxidized cellulose before contacting with the solvent.
12. The medical device according to claim 10 , wherein the at least one of the fiber, the coating, or the film are formed by evaporating the solvent from the oxidized cellulose solution.
13. The medical device according to claim 12 , wherein the at least one of the fiber, the coating, or the film are formed by depositing the modified oxidized cellulose solution on a substrate and evaporating the solvent from the oxidized cellulose solution.
14. The medical device according to claim 10 , wherein the solvent includes N,N-Dimethylacetamide, N-methyl-2-pyrrolidinone, or combinations thereof.
15. The medical device according to claim 10 , wherein the salt includes lithium halides, sodium halides, potassium halides, or combinations thereof.
16. The medical device according to claim 10 , wherein the oxidized cellulose solution is contacted with at least one biocompatible plasticizer.
17. The medical device according to claim 16 , wherein the at least one biocompatible plasticizer includes lecithin, dibutyl sebacate, citric acid, polyethylene glycol, polypropylene glycol, or combinations thereof.