Polyalkoxy fatty compound
View Patent ↗Provided is a composition comprising one or more protein and one or more polyalkoxy fatty compound and wherein said polyalkoxy fatty compound has structure (I) wherein R 1 is a fatty group; R 2 is H or a substituted or unsubstituted hydrocarbyl group; n is 0 to 5; X 1 is O, S, or NH; X 2 is O, S, or NH; and R 3 is a polymeric group comprising polymerized units of (II) and (III)
1. A composition comprising water, one or more protein, and one or more polyalkoxy fatty compound that has structure (I)
wherein R 1 is a fatty group; R 2 is H or a substituted or unsubstituted hydrocarbyl group; n is 0 to 5; X 1 is O, S, or NH; X 2 is O, S, or NH; R 3 has the structure R 4 —CH 3 , where R 4 is a polymeric group consisting of polymerized units of (II) and (III); and R 3 has number-average molecular weight of 600 or higher
2. The composition of claim 1 , wherein the polyalkoxy fatty compound is present in an amount of 0.01 mg/mL or more.
3. The composition of claim 1 , wherein the protein is present in an amount of 400 mg/mL or less.
4. The composition of claim 1 , wherein the water is present in an amount of 50% or more, by weight based on the weight of said composition, wherein said protein and said polyalkoxy fatty compound are dissolved or dispersed in said water.
5. The composition of claim 1 , wherein the water is present in an amount of 50% or more, by weight based on the weight of said composition, wherein said protein and said polyalkoxy fatty compound are dissolved in said water.
6. The composition of claim 1 , wherein said composition further comprises one or more additional ingredients, wherein the total amount of all additional ingredients is 300 mg/mL or less.
7. The composition of claim 1 , wherein said protein is selected from monoclonal antibodies, growth factors, insulins, immunoglobulins, polyclonal antibodies, hormones, enzymes, polypeptides, fusions of peptides, glycosylated proteins, antigens, antigen subunits, and combinations thereof.
8. The composition of claim 1 ,
wherein —R 1 is a linear unsubstituted alkyl group having 10 to 16 carbon atoms,
wherein —R 2 is selected from the group consisting of hydrogen, methyl, and —CH 2 —(C 6 H 5 ),
wherein —(C 6 H 5 ) is a benzene ring, and
wherein —R 3 has number-average molecular weight from 800 to 3000.
9. The composition of claim 1 , wherein X 2 is NH.
10. The composition of claim 1 , wherein n is 0 or 1.
11. The composition of claim 1 , wherein X 1 is NH.
12. A composition comprising water, one or more protein, and one or more polyalkoxy fatty compound that has structure (I)
wherein R 1 is a fatty group; R 2 is H or a substituted or unsubstituted hydrocarbyl group; n is 1 to 5; X 1 is O, S, or NH; X 2 is O, S, or NH; and R 3 is a polymeric group comprising polymerized units of (II) and (III)
13. The composition of claim 12 , wherein the polyalkoxy fatty compound is present in an amount of 0.01 mg/mL or more.
14. The composition of claim 12 , wherein the protein is present in an amount of 400 mg/mL or less.
15. The composition of claim 12 , wherein the water is present in an amount of 50% or more, by weight based on the weight of said composition, wherein said protein and said polyalkoxy fatty compound are dissolved or dispersed in said water.
16. The composition of claim 12 , wherein the water is present in an amount of 50% or more, by weight based on the weight of said composition, wherein said protein and said polyalkoxy fatty compound are dissolved in said water.
17. The composition of claim 12 , wherein said composition further comprises one or more additional ingredients, wherein the total amount of all additional ingredients is 300 mg/mL or less.
18. The composition of claim 12 , wherein said protein is selected from monoclonal antibodies, growth factors, insulins, immunoglobulins, polyclonal antibodies, hormones, enzymes, polypeptides, fusions of peptides, glycosylated proteins, antigens, antigen subunits, and combinations thereof.
19. The composition of claim 12 ,
wherein —R 1 is a linear unsubstituted alkyl group having 10 to 16 carbon atoms,
wherein —R 2 is selected from the group consisting of hydrogen, methyl, and —CH 2 —(C 6 H 5 ),
wherein —(C 6 H 5 ) is a benzene ring, and
wherein —R 3 has number-average molecular weight from 800 to 3000.
20. The composition of claim 12 , wherein X 2 is NH.
21. The composition of claim 12 , wherein n is 1.
22. The composition of claim 12 , wherein X 1 is NH.