Pump homeostasis indicator (PHI)

1. A method of determining adverse events from operation of an implantable blood pump, comprising:

calculating a moving average convergence divergence (MACD) based on power consumed by the implantable blood pump to maintain a constant rotational speed of an impeller of the implantable blood pump; and

generating an alert when the calculated MACD diverges from a predetermined MACD threshold and exceeds a predetermined MACD zero-crossing time threshold.

2. The method of claim 1 , wherein calculating the MACD includes calculating a slow moving average (SMA), and wherein the SMA is an average measurement of the power consumed by the implantable blood pump measured at a predetermined interval for a first predetermined period of time.

3. The method of claim 2 , wherein the predetermined interval is 15 minutes.

4. The method of claim 2 , wherein the first predetermined period of time is 48 hours.

5. The method of claim 4 , wherein calculating the MACD includes calculating a fast moving average (FMA), and wherein the FMA is an average measurement of the power consumed by the implantable blood pump measured at the predetermined interval for a second predetermined period of time less the first period of time.

6. The method of claim 5 , wherein the second predetermined period of time is four hours.

7. The method of claim 1 , wherein the predetermined MACD threshold is at least one from the group consisting of a minimum MACD value and a maximum MACD value over a continuous 48 hour period multiplied by 150%.

8. The method of claim 1 , wherein the predetermined MACD zero-crossing time threshold is 24 hours.

9. The method of claim 1 , wherein the alert is generated at a time of the later of the occurrence of:

when the calculated MACD diverges from the predetermined MACD threshold; and

when the calculated MACD exceeds the predetermined MACD zero-crossing time threshold.

10. The method of claim 1 , wherein the method further includes clearing the alert when the MACD crosses a zero line of the MACD.

11. The method of claim 1 , wherein the method further includes calculating a first average power consumed by the implantable blood pump measured at a predetermined interval for a third predetermined period of time;

calculating a second average power consumed by the implantable blood pump measured at the predetermined interval for a fourth predetermined period of time greater than the first period of time;

generating the alert when the calculated first average power consumed by the implantable blood pump deviates from the calculated second average power consumed by the implantable blood pump by two standard deviations.

12. The method of claim 11 , wherein the third predetermined period of time is three hours.

13. The method of claim 11 , wherein the fourth predetermined period of time is five days.

14. The method of claim 11 , wherein the method further includes clearing the alert when the first average power consumed by the implantable blood pump converges to the calculated second average power consumed by the implantable blood pump by less than two standard deviations.

15. The method of claim 1 , wherein generating the alert is indicative of at least one from the group consisting of thrombus, gastrointestinal bleeding, tachycardia, arrhythmia, and right heart failure.

16. A system for determining adverse events from operation of an implantable blood pump, comprising:

a controller having a processor, the controller being in communication with the implantable blood pump and a power source configured to provide power to the implantable blood pump, the controller being configured to:

calculate a moving average convergence divergence (MACD) based on power consumed by the implantable blood pump to maintain a constant rotational speed of an impeller of the implantable blood pump; and

generate an alert when the calculated MACD diverges from a predetermined MACD threshold.