Treatment of gastrointestinal bleeding in patients with severe von Willebrand disease by administration of recombinant VWF
The present invention relates to a method for treating gastrointestinal bleeding in a subject with severe von Willebrand Disease comprising administering to the subject at least one dose of recombinant von Willebrand Factor (rVWF) ranging from about 40 IU/kg to about 100 IU/kg, wherein the first dose further comprises recombinant Factor VIII (rFVIII).
1. A method for treating gastrointestinal bleeding in a subject with severe von Willebrand Disease (VWD) comprising administering to the subject at least one dose of recombinant von Willebrand Factor (rVWF) ranging from about 40 IU/kg to about 100 IU/kg, wherein the first dose further comprises recombinant Factor VIII (rFVIII) and wherein said rVWF to FVIII ratio is selected from the group consisting of about 1.5:0.8, about 1.3:1, about 1.1:0.8, about 1.5:1, and about 1.1:1.2.
2. The method of treatment of claim 1 , wherein said rFVIII is administered at a dose of about 20 IU/kg to about 50 IU/kg.
3. The method of treatment of claim 1 , wherein said method further comprises administering to the subject a second dose of recombinant von Willebrand Factor (rVWF) ranging from about 40 IU/kg to about 100 IU/kg, wherein the second dose does not comprise recombinant Factor VIII (rFVIII).
4. The method of treatment of claim 1 , wherein said rVWF to rFVIII ratio is about 1.5:0.8.
5. The method of treatment of claim 1 , wherein said rVWF to rFVIII ratio is about 1.3:1.
6. The method of treatment of claim 1 , wherein said rVWF to rFVIII ratio is about 1.1:0.8.
7. The method of treatment of claim 1 , wherein said rVWF to rFVIII ratio is about 1.5:1.
8. The method of treatment of claim 1 , wherein said rVWF to rFVIII ratio is about 1.1: 1.2.
9. The method of treatment of claim 1 , wherein said rVWF is administered every 8 to 12 hours.
10. The method of treatment of claim 1 , wherein 40-60 IU/kg rVWF of said rVWF is administered and wherein said gastrointestinal bleeding is minor or moderate gastrointestinal bleeding.
11. The method of treatment of claim 1 , wherein 40-80 IU/kg rVWF of said rVWF and wherein said gastrointestinal bleeding is major or severe gastrointestinal bleeding.
12. The method of treatment of claim 1 , wherein said rVWF is administered every 8 to 12 hours for about 3 days to about 7 days.
13. The method of treatment of claim 1 , wherein 40-60 IU/kg rVWF of said rVWF is administered every 8 to 12 hours for about 3 days to about 7 days, wherein said gastrointestinal bleeding is minor or moderate gastrointestinal bleeding.
14. The method of treatment of claim 1 , wherein 40-80 IU/kg rVWF of said rVWF is administered every 8 to 12 hours for about 3 days to about 7 days, wherein said gastrointestinal bleeding is major or severe gastrointestinal bleeding.
15. The method of treatment of claim 1 , wherein said subject has Type 3 VWD.
16. The method of treatment of claim 1 , wherein said subject has severe type 1 VWD.
17. The method of treatment of claim 1 , wherein said subject has severe type 2 VWD.
18. The method of claim 1 , wherein the subject had been treated for at least 1 bleeding event within the previous 12 months.
19. The method of claim 1 , wherein the subject had been treated for more than 1 bleeding event within the previous 12 months.