Pesticidal compositions and uses thereof
Provided herein are compounds that exhibit activity as fungicides and are useful, for example, in methods for the control of fungal pathogens in plants and can be applied to said plants in a variety of ways.
1. A method of controlling an agricultural fungal pathogen, the method comprising administering to a plant, a seed or soil a composition comprising a compound selected from the group consisting of:
(R)-ethyl-1-(2-(2-cyanoethoxy)-2-(5-fluoro-2-methoxyphenyl)ethyl)-3-(1-(isopropylamino)-2-methyl-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate;
(R)-ethyl-1-(2-(5-fluoro-2-methoxyphenyl)-2-(2-hydroxyethoxy)ethyl)-3-(1-(isopropylamino)-2-methyl-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate;
(R)-2-(1-(2-(2-cyanoethoxy)-2-(2-methoxyphenyl)ethyl)-5-methyl-2,4-dioxo-6-(1H-pyrazol-1-yl)-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-N-isopropyl-2-methylpropanamide;
(R)-2-(1-(2-(2-cyanoethoxy)-2-(2-methoxyphenyl)ethyl)-5-methyl-2,4-dioxo-6-(2H-1,2,3-triazol-2-yl)-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-N-isopropyl-2-methylpropanamide;
(R)-2-(1-(2-(2-cyano-2-methylpropoxy)-2-(5-fluoro-2-methoxyphenyl)ethyl)-5-methyl-2,4-dioxo-6-(2H-1,2,3-triazol-2-yl)-1,4-dihydrothieno [2,3-d]pyrimidin-3 (2H)-yl)-N-isopropyl-2-methylpropanamide;
(R)-ethyl-1-(2-(2-cyanoethoxy)-2-(5-fluoro-2-methoxyphenyl)ethyl)-3-((R)-1-(isopropylamino)-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate;
(R)-ethyl-1-(2-(2-cyanoethoxy)-2-(5-fluoro-2-methoxyphenyl)ethyl)-3-(1-(ethylamino)-2-methyl-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate;
(R)-ethyl-1-(2-(2-cyanoethoxy)-2-(2-methoxyphenyl)ethyl)-3-(1-(isopropylamino)-2-methyl-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate; and
(R)-ethyl-1-(2-(2-cyanoethoxy)-2-(2-methoxyphenyl)ethyl)-3-(1-(ethylamino)-2-methyl-1-oxopropan-2-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate;
or a salt thereof.
2. The method of claim 1 , wherein the composition further comprises a surfactant.
3. The method of claim 1 , wherein the composition further comprises a co-solvent.
4. The method of claim 1 , wherein the composition further comprises a biological control agent, microbial extract, natural product, plant growth activator plant defense agent, or a mixture thereof.
5. The method of claim 1 , wherein the composition further comprises an additional pesticide, wherein the additional pesticide is a fungicide, an insecticide, a herbicide, or a mixture thereof.
6. The method of claim 1 , wherein the composition further comprises an additional pesticide, wherein the additional pesticide is fluoxastrobin, fluxapyroxad, ipconazole, mefenoxam, metalaxyl, penflufen, prothioconazole, pyraclostrobin, trifloxystrobin, abamectin, clothianidin, imidacloprid, thiamethoxam, or a mixture thereof.
7. The method of claim 1 , wherein the composition further comprises tioxazafen.
8. The method of 1 , wherein the method comprises administering the composition to a seed.
9. A treated seed prepared according to the method of claim 1 .
10. The method of claim 1 , wherein the method comprises exogenously administering the composition to a plant.
11. The method of claim 10 , wherein the composition is applied to foliage of the plant.
12. The method of claim 10 , wherein the method comprises applying the composition to soil surrounding a root zone of the plant.
13. The method of claim 10 , wherein the composition is applied directly to a base of the plant or to soil immediately adjacent to the plant.
14. The method of claim 1 , wherein the agricultural fungal pathogen is selected from Ascomycetes, Deuteromycetes, Oomycetes, and Basidiomycetes.
15. The method of claim 1 , wherein the agricultural fungal pathogen is Blumeria graminis, Microsphaera spp., Podosphaera spp., Uncinula necator, Fusarium graminearum, Fusarium moniliforme, Fusarium virguliforme, Botrtyis cinerea, Sclerotinia sclerotiorum, Alternaria alternata, Alternaria solani, Collectotrichum graminicola, Cercospora spp., Septoria (Zymoseptoria) tritici, Rhizoctonia solani, Puccinia spp., Puccinia triticina, Phakopsora pachyrhizi, Diplodia maydis, Phytophthora capsici, Pythium spp., or Pythium ultimum.
16. The method of claim 1 , wherein the composition further comprises a biological control agent, wherein the biological control agent is Bacillus firmus.