Device for packaging and dispensing a substance for ophthalmic use
View Patent ↗Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution including a dispensing accessory with a first valve made of an elastomer material that allows the substance to pass through when the dispensing accessory is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory is relaxed, characterized in that the first valve is covered by a layer of Parylene.
1. A device for packaging and dispensing drops of a product for ophthalmic use, fluid, semifluid or in suspension, emulsion or oily solution, comprising a dispensing accessory comprising a first valve made of elastomer material allowing passage of the product when the dispensing accessory is stressed without allowing outside air to move in a reverse direction when the dispensing accessory is relaxed, wherein the first valve is covered with a layer of parylene,
wherein the dispensing accessory is a dispensing accessory for calibrated drops comprising:
a supple membrane whereof a stress causes dispensing of the product,
a dispensing chamber of the product delimited at least by:
a first portion of a periphery of a rigid core and
a part of elastically deformable flexible membrane located facing the first portion, the flexible membrane extending about the rigid core,
the first valve made of elastomer material allowing the product to enter the dispensing chamber when the supple membrane is stressed without allowing outside air to move in the reverse direction when the supple membrane is relaxed,
wherein the device comprises form-holding means of the supple membrane, relative to at least one second portion of the periphery of the rigid core, the form-holding means comprising:
at least one rigid piece attached to the supple membrane and extending opposite the second portion of the periphery of the rigid core, the rigid piece being located between the supple membrane and the second portion of the periphery of the rigid core, or
a rigid piece attached to a part of the supple membrane extending opposite the second portion of the periphery of the rigid core, the part of the supple membrane being located between the rigid piece and the second portion of the periphery of the rigid core, or
an assembly of the supple membrane with a surface of the second portion of the periphery of the rigid core by adhesion or welding.
2. The device according to claim 1 , comprising:
a container intended to contain the product and dispense it, the dispensing accessory being mounted on the container and the first valve allowing the product to exit the container when the dispensing accessory is stressed without allowing outside air to enter the container when the dispensing accessory is relaxed,
a renewal and filtration assembly of the air entering the container after dispensing of a product portion or dose, comprising a second valve made of elastomer material and covered with a layer of parylene, allowing outside air to enter said container when the dispensing accessory is relaxed without allowing the product or substantially the air contained inside the container to exit when the dispensing accessory is stressed.
3. The device according to claim 2 , wherein the second valve has a form comprising:
a substantially plane circular form having two faces, a first face being turned towards the interior of the container and delimited by an outer rim, and
a protuberance extending over a central area of the circular form delimited by an inner diameter, engaged with the circular form, extending perpendicularly to the circular form on either side of the circular form.
4. The device according to claim 1 , wherein the first valve has a hat shape, comprising:
a central cylindrical form, and
a peripheral circumferential protuberance.
5. The device according to claim 2 , wherein the first valve has a substantially plane circular shape delimited by an outer rim and is adapted to allow passage of the product:
by deformation at the level of a central area, the outer rim of the first valve being held in position by forces applied on either side of the first valve, or
by deformation of the outer rim, a central area of the valve being held in position by forces applied on either side of the first valve.
6. The device according to claim 5 , wherein a thickness of the first and/or second valve(s) increases between the central area and the outer rim.
7. The device according to claim 5 , wherein the first and/or second valve(s) at rest has a curve profile and/or has at least one angle.
8. The device according to claim 5 , wherein the form of the first and/or second valve(s) has at least one circumferential protuberance extending over at least one face of the first and/or of the second valve(s).
9. The device according to claim 5 , wherein the first valve has a substantially plane annular form delimited by:
an inner diameter between 5 and 10 mm and
an outer diameter of between 11 and 20 mm,
the outer diameter having a thickness of between 0.25 and 2.5 mm.
10. The device according to claim 2 , wherein the elastomer material of the first and/or second valve(s) is silicone.
11. The device according to claim 2 , wherein the elastomer material of the first and/or second valve(s) is thermoplastic elastomer with polyolefin base, or styrene-based thermoplastic elastomer or thermoplastic polyurethane.
12. The device according to claim 1 , wherein:
the dispensing chamber has a general trapezoid form in cross-section, and/or
the part of the supple membrane delimiting the dispensing chamber forms a generally prismatic piece which comprises two ends each having an area of lesser thickness.
13. Use of the device according to claim 1 , comprising:
packaging a product for ophthalmic use in the device according to claim 1 ; and
dispensing drops of the product for ophthalmic use from the device according to claim 1 ,
wherein the product for ophthalmic use comprises an analog of prostaglandin.
14. Use of the device according to claim 1 , comprising:
packaging a product for ophthalmic use in the device according to claim 1 ; and
dispensing drops of the product for ophthalmic use from the device according to claim 1 ,
wherein the product for ophthalmic use comprises a corticoid.
15. Use of the device according to claim 1 , comprising:
packaging a product for ophthalmic use in the device according to claim 1 ; and
dispensing the product for ophthalmic use from the device according to claim 1 ,
wherein the product for ophthalmic use comprises a non-steroidal anti-inflammatory.
16. Manufacturing process of a device according to claim 2 , wherein it comprises:
moulding a first and/or second valve(s) made of elastomer,
parylene processing of the first and/or second valve(s) made of elastomer for covering its surface with a coating of parylene,
mounting of the device with the resulting first and/or second valve(s).
17. A device for packaging and dispensing drops of a product for ophthalmic use, fluid, semi-fluid or in suspension, emulsion or oily solution, comprising a dispensing accessory comprising a first valve made of elastomer material allowing passage of the product when the dispensing accessory is stressed without allowing outside air to move in the reverse direction when the dispensing accessory is relaxed, wherein the first valve is covered with a layer of parylene,
wherein the dispensing accessory is a dispensing accessory for calibrated drops comprising:
a supple membrane whereof a stress causes dispensing of the product,
a dispensing chamber of the product delimited at least by:
a first portion of a periphery of a rigid core and
a part of elastically deformable flexible membrane located facing the first portion, the flexible membrane extending about the rigid core,
the first valve made of elastomer material allowing the product to enter the dispensing chamber when the supple membrane is stressed without allowing outside air to move in the reverse direction when the supple membrane is relaxed,
wherein
the dispensing chamber has a general trapezoid form in cross-section, and/or
the part of the supple membrane delimiting the dispensing chamber forms a generally prismatic piece which comprises two ends each having an area of lesser thickness.