Hemostatic compostions
The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide, and optionally, at least one compound selected from coagulation factors and glycosaminoglycans. The invention further relates to a method for preparing such composition, and to a unit comprising such composition and a spraying device.
1. A hemostatic composition, comprising:
collagen of the fibrillar type comprising a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen,
at least one monosaccharide, and
chondroitin sulfate in a content ranging from 2% to 25% by weight relative to the total weight of the composition,
wherein the composition is in powder form.
2. The composition of claim 1 , wherein said chondroitin sulfate is in a content ranging from 3% to 20% by weight relative to the total weight of the composition.
3. The composition of claim 1 , wherein said chondroitin sulfate is in a content ranging from 4% to 15% by weight relative to the total weight of the composition.
4. The composition of claim 1 , wherein said chondroitin sulfate is in a content ranging from 5% to 12.5% by weight relative to the total weight of the composition.
5. The composition of claim 1 , wherein said composition comprises a collagen content ranging from 70% to 99% by weight relative to the total weight of the composition.
6. The composition of claim 1 , wherein said composition comprises a collagen content ranging from 75% to 96% by weight relative to the total weight of the composition.
7. The composition of claim 1 , wherein said composition comprises a collagen content ranging from 77% to 93% by weight relative to the total weight of the composition.
8. The composition of claim 1 , wherein said composition comprises a collagen content ranging from 80% to 90% by weight relative to the total weight of the composition.
9. The composition of claim 1 , wherein said composition comprises a monosaccharide content ranging from 1% to 10% by weight relative to the total weight of the composition.
10. The composition of claim 1 , wherein said composition comprises a monosaccharide content ranging from 1% to 12.5% by weight relative to the total weight of the composition.
11. The composition of claim 1 , wherein said composition comprises a monosaccharide content ranging from 1.5% to 10% by weight relative to the total weight of the composition.
12. The composition of claim 1 , wherein said composition comprises a monosaccharide content ranging from 2% to 8% by weight relative to the total weight of the composition.
13. The composition of claim 1 , wherein said composition comprises a monosaccharide content ranging from 2.5% to 7.5% by weight relative to the total weight of the composition.
14. The composition of claim 1 , wherein said composition comprises a collagen/monosaccharide weight ratio ranging from 10 to 50.
15. The composition of claim 1 , wherein said composition comprises a collagen/monosaccharide weight ratio of 19.
16. The composition of claim 1 , wherein the collagen comprises a content of fibrous collagen and/or fibrillar collagen ranging from 85% to 95% by weight relative to the total weight of the collagen.
17. The composition of claim 1 , wherein said composition further comprises a collagen/total carbohydrate compounds weight ratio ranging from 2 to 40, wherein the weight of the total carbohydrate compounds is the sum of the weight of the monosaccharide(s) and the weight of the chondroitin sulfate.
18. The composition of claim 1 , wherein said composition further comprises a coagulation factor in an amount ranging from 0.01 IU/mg to 20 IU/mg of the composition.
19. The composition of claim 1 , wherein said composition further comprises thrombin as coagulation factor in an amount ranging from 0.01 IU/mg to 20 IU/mg of the composition.
20. The composition of claim 1 , wherein said composition has a tapped density greater than 0.4 g/mL.
21. The composition of claim 1 , wherein said composition comprises at least 50% by weight of particles whose size is between 200 μm and 400 μm.
22. The composition of claim 1 wherein:
the collagen is in an amount of at least 85% by weight relative to the total weight of the composition,
the monosaccharide is in an amount ranging from 4% to 6% by weight relative to the total weight of the composition,
the chondroitin sulfate is in an amount ranging from 7.2% to 10.8% by weight relative to the total weight of the composition.
23. The composition of claim 22 , further comprising thrombin, in an amount of 0.2 IU/mg to 2 IU/mg of the composition.
24. A method for preparing a hemostatic composition comprising at least the following steps:
a) formation of an aqueous suspension comprising a collagen of fibrillar type having a content of fibrous collagen and/or fibrillar collagen of at least 70% by weight relative to the total weight of the collagen, and at least one monosaccharide,
b) recovery of a product from the aqueous suspension comprising the collagen and monosaccharide in the form of a precipitate, paste or gel,
c) drying of the product,
d) grinding of the product to the desired granulometry,
e) adding chondroitin sulfate to the product in a content ranging from 2% to 25% by weight relative to the total weight of the composition.
25. The method of claim 24 , wherein in the step b) the recovery of the product is carried by centrifugation or decantation.
26. The method of claim 24 , wherein the collagen used in step a) is obtained by basic extraction.
27. The method of claim 24 , wherein in step e) is further added thrombin to the product.
28. A method of treating a wound, which comprises administering the composition of claim 1 to the wound.
29. A kit comprising:
the composition of claim 1 , and
a spraying device.