L-ornithine phenyl acetate and methods of making thereof
View Patent ↗Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
1. A process for making L-ornithine phenylacetate, comprising:
forming a solution of L-ornithine;
adding a pH modifier to the solution;
adding phenylacetic acid to the solution; and
isolating L-ornithine phenylacetate from the solution.
2. The process of claim 1 , wherein the solution comprises water.
3. The process of claim 1 , wherein said isolating L-ornithine phenylacetate from the solution comprises a filtration of the solution.
4. The process of claim 1 , wherein said isolating L-ornithine phenylacetate from the solution comprises crystallizing L-ornithine phenylacetate from the solution.
5. The process of claim 4 , wherein said crystallizing L-ornithine phenylacetate further comprises cooling the solution.
6. The process of claim 4 , further comprising adding a second solvent to the solution.
7. The process of claim 6 , wherein the second solvent comprises one or more alcohols.
8. The process of claim 7 , wherein the one or more alcohols are selected from the group consisting of methanol, ethanol, 1-propanol, isopropanol, ethylene glycol, 2-butanol, 3-methyl-1-butanol, and combinations thereof.
9. The process of claim 8 , wherein the second solvent comprises ethanol.
10. The process of claim 6 , wherein said crystallizing L-ornithine phenylacetate comprises cooling the solution.
11. The process of claim 10 , further comprising recrystallizing the isolated L-ornithine phenylacetate.
12. The process of claim 4 , wherein said crystallizing provides a composition comprising a crystalline form of L-ornithine phenylacetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of peaks at approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ.
13. The process of claim 4 , wherein said crystallizing provides a composition comprising a crystalline form of L-ornithine phenylacetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of peaks at approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ.
14. The process of claim 4 , wherein said crystallizing provides a composition comprising a crystalline form of L-ornithine phenylacetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of peaks at approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ.
15. The process of claim 6 , wherein said crystallizing provides a composition comprising a crystalline form of L-ornithine phenylacetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of peaks at approximately 6.0°, 13.9°, 14.8°, 17.1°, 17.8° and 24.1° 2θ.
16. The process of claim 6 , wherein said crystallizing provides a composition comprising a crystalline form of L-ornithine phenylacetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of peaks at approximately 5.8°, 14.1°, 18.6°, 19.4°, 22.3° and 24.8° 2θ.
17. The process of claim 6 , wherein said crystallizing provides a composition comprising a crystalline form of L-ornithine phenylacetate, wherein said crystalline form exhibits an X-ray powder diffraction pattern comprising at least three characteristic peaks, wherein said characteristic peaks are selected from the group consisting of peaks at approximately 4.9°, 13.2°, 17.4°, 20.8° and 24.4° 2θ.