Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases
View Patent ↗A formulation, especially one that is topically administered, comprising a combination of rapamcycin and metformin in a molar ratio of about 20:1, 10:1, 5:1, 4:1, 3:1, or 1:1. The topical formulation may be a gel, an ointment, a cream or a lotion. The topical formulation may be used to treat a condition or disease of the skin or eye, wherein the condition or disease is associated with mTORC1 activation.
1. A composition for topical administration comprising a combination of rapamycin and metformin, wherein the rapamycin is present in an amount in a range of about 0.01% to about 4.0% by weight and the metformin is present in an amount in a range of about 0.00007% to about 2.0% by weight, wherein the molar ratio of rapamycin to metformin is in the range of about 20:1 to about 1:1.
2. The composition of claim 1 , wherein the rapamycin is present in an amount in a range of about 0.1% to about 3.5% and the metformin in present in an amount in a range of about 0.002% to about 1.0% by weight.
3. The composition of claim 1 , wherein the rapamycin in present in an amount of up to about 3.5% by weight and the metformin is present in an amount of up to about 2.0% by weight.
4. The composition of claim 1 , wherein the amount of rapamycin is less than about 2.0% by weight.
5. The composition of claim 1 , wherein the amount of metformin is less than about 1.5% by weight.
6. The composition of claim 1 , wherein the composition is in a form selected from a gel, an ointment, a cream, a lotion, or liquid solution.
7. The composition of claim 1 , wherein the composition is in a form for topical mucosal administration.
8. The composition of claim 7 , wherein the composition is in a form selected from drops or aerosols.
9. The composition of claim 1 , wherein the molar ratio of rapamycin to metformin is in the range of about 15:1 to about 1:1.
10. The composition of claim 1 , wherein the molar ratio of rapamycin to metformin is in the range of about 10:1 to about 4:1.
11. The composition of claim 1 , wherein the molar ratio of rapamycin to metformin is in the range of about 5:1 to about 1:1.
12. The composition of claim 1 , wherein the molar ratio of rapamycin to metformin is in the range of about 5:1 to about 3:1.
13. The composition of claim 1 , wherein the molar ratio of rapamycin to metformin is in the range of about 5:1 to 4:1.