Granted Patent
B2
US 10,584,114 · App. 16/041,719 · Granted Mar 10, 2020
Inhibitors of RET
Inventors:
Jason D. Brubaker (Cambridge, MA); Joseph L. Kim (Wayland, MA); Kevin J. Wilson (Boston, MA); Douglas Wilson (Ayer, MA); Lucian V. DiPietro (Gloucester, MA)
Assignee:
BLUEPRINT MEDICINES CORPORATION
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Abstract
Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
Claims (3)
1. A compound which is:
2. A compound which is:
3. A compound which is:
Assignments (8)
SECURITY INTEREST
Recorded May 8, 2026
From: RIGEL PHARMACEUTICALS, INC.
To: MIDCAP FUNDING IV TRUST
Reel/Frame 075576/0880 →
RELEASE OF SECURITY INTEREST (REEL/FRAME NUMBER 060616/0923)
Recorded Jul 23, 2025
From: TAO TALENTS, LLC
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 072193/0847 →
SECURITY INTEREST
Recorded May 23, 2024
From: RIGEL PHARMACEUTICALS, INC.
To: MIDCAP FINANCIAL TRUST
Reel/Frame 067509/0146 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 8, 2024
From: BLUEPRINT MEDICINES CORPORATION
To: RIGEL PHARMACEUTICALS, INC.
Reel/Frame 066703/0974 →
RELEASE OF SECURITY INTEREST
Recorded Feb 22, 2024
From: TAO TALENTS, LLC, AS ADMINISTRATIVE AGENT
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 066536/0717 →
SECURITY INTEREST
Recorded Jul 8, 2022
From: BLUEPRINT MEDICINES CORPORATION
To: TAO TALENTS, LLC
Reel/Frame 060616/0923 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 20, 2018
From: BRUBAKER, JASON D.; KIM, JOSEPH L.; WILSON, KEVIN J.; WILSON, DOUGLAS; DIPIETRO, LUCIAN V.
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 046420/0943 →
ASSIGNEE CHANGE OF ADDRESS
Recorded Jul 20, 2018
From: BLUEPRINT MEDICINES CORPORATION
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 046635/0675 →
Continuity (4)
Provisional Application
62367960
· Jul 28, 2016
Provisional Application
62249784
· Nov 2, 2015