Drug combinations and uses in treating a coughing condition
The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a coughing condition with such compositions.
1. A method of treating a non-productive coughing condition, the method comprising the step of administering a therapeutically-effective amount of an oral pharmaceutical composition to an individual in need thereof, the oral pharmaceutical composition comprising 0.5 mg/mL to 10 mg/mL of Theobromine, 0.25 mg/mL to 7.5 mg/mL of Diphenhydramine, and 0.1 mg/mL to 5 mg/mL of Phenylephrine,
wherein the pharmaceutical composition does not include a non-opiate antitussive agent,
wherein the therapeutically-effective amount of the theobromine is at least 60 mg/day and at most 150 mg/day, and
wherein administration reduces a symptom associated with the coughing condition.
2. The method according to claim 1 , wherein the oral pharmaceutical composition comprises 0.5 mg/mL to 6 mg/mL of Theobromine, 0.5 mg/mL to 5 mg/mL of Diphenhydramine, and 0.1 mg/mL to 3 mg/mL of Phenylephrine.
3. The method according to claim 1 , wherein the oral pharmaceutical composition comprises 0.5 mg/mL to 4 mg/mL of Theobromine, 0.5 mg/mL to 3 mg/mL of Diphenhydramine, and 0.1 mg/mL to 2 mg/mL of Phenylephrine.
4. The method according to claim 1 , wherein the oral pharmaceutical composition comprises 1 mg/mL to 3 mg/mL of Theobromine, 0.5 mg/mL to 2 mg/mL of Diphenhydramine, and 0.1 mg/mL to 1 mg/mL of Phenylephrine.
5. The method according to claim 1 , wherein the oral pharmaceutical composition comprises 2 mg/mL of Theobromine, 1.25 mg/mL of Diphenhydramine, and 0.5 mg/mL of Phenylephrine.
6. The method according to claim 1 , wherein the therapeutically-effective amount of the oral pharmaceutical composition administered to the individual comprises between 60 mg/day and 150 mg/day of Theobromine, 20 mg/day and 100 mg/day of Diphenhydramine, and 5 mg/day and 50 mg/day of Phenylephrine.
7. The method according to claim 6 , wherein the therapeutically-effective amount of the oral pharmaceutical composition administered to the individual comprises between 60 mg/day and 120 mg/day of Theobromine, 37.5 mg/day and 75 mg/day of Diphenhydramine, and 15 mg/day and 30 mg/day of Phenylephrine.
8. The method according to claim 1 , wherein the non-productive coughing condition comprises an acute coughing condition, a subacute coughing condition, or a chronic coughing condition.
9. A method of treating a non-productive coughing condition, the method comprising the step of administering a therapeutically-effective amount of an oral pharmaceutical composition to an individual in need thereof, the oral pharmaceutical composition comprising 0.5 mg/mL to 6 mg/mL of Theobromine, 0.25 mg/mL to 4 mg/mL of Diphenhydramine, and 0.1 mg/mL to 3 mg/mL of Phenylephrine,
wherein the pharmaceutical composition does not include a non-opiate antitussive agent,
wherein the therapeutically-effective amount of the theobromine is at most 250 mg/day, and
wherein administration reduces a symptom associated with the coughing condition.
10. The method according to claim 9 , wherein the therapeutically-effective amount of the oral pharmaceutical composition administered to the individual comprises between 60 mg/day and 150 mg/day of Theobromine, 20 mg/day and 100 mg/day of Diphenhydramine, and 5 mg/day and 50 mg/day of Phenylephrine.
11. The method according to claim 10 , wherein the therapeutically-effective amount of the oral pharmaceutical composition administered to the individual comprises between 60 mg/day and 120 mg/day of Theobromine, 37.5 mg/day and 75 mg/day of Diphenhydramine, and 15 mg/day and 30 mg/day of Phenylephrine.
12. A method of treating a non-productive coughing condition, the method comprising the step of administering a therapeutically-effective amount of an oral pharmaceutical composition to an individual in need thereof, the pharmaceutical composition comprising 0.5 mg/mL to 4 mg/mL of Theobromine, 0.5 mg/mL to 3 mg/mL of Diphenhydramine, and 0.1 mg/mL to 2 mg/mL of Phenylephrine,
wherein the pharmaceutical composition does not include a non-opiate antitussive agent,
wherein the therapeutically-effective amount of the theobromine is at most 250 mg/day, and
wherein administration reduces a symptom associated with the coughing condition.
13. The method according to claim 12 , wherein the oral pharmaceutical composition comprises 1 mg/mL to 3 mg/mL of Theobromine, 0.5 mg/mL to 2 mg/mL of Diphenhydramine, and 0.1 mg/mL to 1 mg/mL of Phenylephrine.
14. The method according to claim 12 , wherein the therapeutically-effective amount of the oral pharmaceutical composition administered to the individual comprises between 60 mg/day and 150 mg/day of Theobromine, 20 mg/day and 100 mg/day of Diphenhydramine, and 5 mg/day and 50 mg/day of Phenylephrine.
15. The method according to claim 14 , wherein the therapeutically-effective amount of the oral pharmaceutical composition administered to the individual comprises between 60 mg/day and 120 mg/day of Theobromine, 37.5 mg/day and 75 mg/day of Diphenhydramine, and 15 mg/day and 30 mg/day of Phenylephrine.