IP Library Granted Patent US 10,645,932
Granted Patent B2
US 10,645,932 · App. 16/045,432 · Granted May 12, 2020

Extended release formulation

Inventors: George Gu (Dallas, TX); Min Xie (Schaumburg, IL); Keith Haas (Schaumburg, IL); Doug Vangundy (Schaumburg, IL)
Assignee: WELLMARK INTERNATIONAL
A01N49/00A01N25/10A01N25/12B01J2/22B01J2/28
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Quick Facts
Patent No.
US 10,645,932
App. No.
16/045,432
Granted
May 12, 2020
Kind
B2
Abstract

The present invention provides an extended release insecticide formulation, the formulation comprising: an insecticide on a substrate; a lipophilic wax, wherein the insecticide is incorporated into the wax forming a matrix; a release retarding polymer embedded in the matrix; and a rate extending polymer embedded in the matrix. Methods of making the formulation and use of the formulation are also provided.

Claims (27)

1. A method of making an extended release insecticide formulation, the method comprising:

i) admixing an insecticide with a lipophilic wax with optional heating to form an admixture of insecticide and lipophilic wax, wherein the insecticide is methoprene;

ii) contacting the admixture of insecticide and lipophilic wax to a substrate to form a matrix;

iii) admixing a water erodible powder, wherein the water erodible powder is calcium sulfate, a release retarding polymer, and a rate extending polymer together to uniformly embed into the matrix and form a powder;

iv) adding a binder with water to the powder to form a dough; and

v) forming a granule from the dough using a granulator, wherein the erodible powder and the rate extending polymer form a water insoluble calcium alginate within the formulation.

2. The method of claim 1 , wherein the insecticide is present between 0.1% to 20% w/w.

3. The method of claim 1 , wherein the substrate is silica.

4. The method of claim 1 , wherein the lipophilic wax is a member selected from the group consisting of an animal wax, a vegetable wax, a petroleum wax, a hydrogenate vegetable oil, or a polyethylene polymer.

5. The method of claim 1 , wherein the lipophilic wax is present in about 1% to about 20% w/w.

6. The method of claim 1 , wherein the release retarding polymer is a member selected from the group consisting of guar gum, xanthan gum, polyurethanes, gelatins, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethylmethylcellulose, hydroxypropylethylcellulose, and a combination thereof.

7. The method of claim 6 , wherein the release retarding polymer is xanthan gum.

8. The method of claim 1 , wherein the binder is polyvinyl alcohol (PVA).

9. The method of claim 1 , wherein the release retarding polymer is present from about 1% to about 20% w/w.

10. The method of claim 1 , wherein the rate extending polymer is present from about 1% to about 10% w/w.

11. A method of making an extended release insecticide formulation for water applications, the method comprising:

i) admixing methoprene with a melted lipophilic wax to form a liquid admixture of insecticide and lipophilic wax;

ii) spraying the liquid admixture of methoprene and lipophilic wax onto a substrate to form a matrix;

iii) admixing calcium sulfate, a release retarding polymer, and a rate extending polymer together with the matrix to form a powder in which the matrix is uniformly embedded with calcium sulfate, the release retarding polymer, and the rate extending polymer;

iv) adding a binder with water to the powder to form a dough; and

v) forming a granule from the dough using a granulator, wherein the erodible powder and the rate extending polymer form a water insoluble calcium alginate within the formulation, which formulation is for use in water.

12. The method of claim 11 , wherein the lipophilic wax is a member selected from the group consisting of an animal wax, a vegetable wax, a petroleum wax, a hydrogenate vegetable oil, and a polyethylene polymer; and wherein the lipophilic wax is present in about 1% to about 20% w/w.

13. The method of claim 11 , wherein the substrate is silica.

14. The method of claim 11 , wherein the release retarding polymer is a member selected from the group consisting of guar gum, xanthan gum, polyurethanes, gelatins, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethylmethylcellulose, hydroxypropylethylcellulose, and a combination thereof.

15. The method of claim 11 , wherein calcium sulfate is present from about 50% to about 85% w/w.

16. The method of claim 1 , wherein the rate extending polymer is sodium alginate.

17. The method of claim 1 , wherein the rate extending polymer is alginic acid.

Assignments (2)
SECURITY INTEREST Recorded Dec 21, 2021
From: ARDEN COMPANIES, LLC; CENTRAL GARDEN & PET COMPANY; FARNAM COMPANIES, INC.; FOUR PAWS PRODUCTS, LTD.; IMS TRADING, LLC; K&H MANUFACTURING, LLC; NEXGEN PLANT SCIENCE CENTER, LLC; T.F.H. PUBLICATIONS, INC.; WELLMARK INTERNATIONAL
To: TRUIST BANK, AS ADMINISTRATIVE AGENT FOR THE SECURED PARTIES
Reel/Frame 058561/0940 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2020
From: GU, GEORGE; XIE, MIN; HAAS, KEITH; VANGUNDY, DOUG
To: WELLMARK INTERNATIONAL
Reel/Frame 052299/0643 →