IP Library Granted Patent US 10,961,258
Granted Patent B2
US 10,961,258 · App. 16/061,497 · Granted Mar 30, 2021

Heterocyclic amides as kinase inhibitors

Inventor: Jae U. Jeong (Collegeville, PA)
Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
C07D513/04A61K9/06A61K9/08A61K9/2013A61K9/2018A61K9/2054A61K9/2059A61K9/4858A61K9/4866A61K47/06C07D487/04C07D491/048C07D495/04
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Quick Facts
Patent No.
US 10,961,258
App. No.
16/061,497
Granted
Mar 30, 2021
Kind
B2
Abstract

Disclosed are compounds having Formula (I): wherein Q, X, A, L, B, Q 4 , R, R A , R 5 , n and m are as defined herein, and methods of making and using the same.

Claims (19)

1. A compound according to Formula (I):

wherein:

X is CH 2;

Q is a 5-membered heteroaryl ring moiety, wherein the heteroaryl ring moiety contains one heteroatom, which heteroatom is a sulfur ring heteroatom;

Q 4 is C;

each R is independently selected from (C 1 -C 6 )alkyl;

n is 0, 1, 2 or 3;

R 5 is H;

A is a 5-6 membered heteroaryl ring comprising one to three heteroatoms, wherein the heteroatom is nitrogen, and wherein the carbonyl moiety and L are substituted 1,3 on ring A;

L is CH 2; and

B is phenyl;

or a pharmaceutically acceptable salt, or a tautomer, thereof.

2. The compound according to claim 1 which is

or a pharmaceutically acceptable salt, or a tautomer, thereof.

3. The compound or pharmaceutically acceptable salt thereof, according to claim 1 , wherein the compound is selected from the group consisting of:

5-benzyl-N-(6,8-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-thieno[3,4-b]azepin-3-yl)-4H-1,2, 4-triazole-3-carboxamide;

5-benzyl-N-(5-oxo-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-6-yl)-4H-1,2, 4-triazole-3-carboxamide; and

5-benzyl-N-(2-methyl-5-oxo-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-6-yl)-4H-1,2, 4-triazole- 3-carboxamide;

or a tautomer thereof.

Assignments (2)
CHANGE OF ADDRESS Recorded Oct 8, 2025
From: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Reel/Frame 073032/0390 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 12, 2018
From: JEONG, JAE U.
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Reel/Frame 046056/0604 →
Continuity (2)
Provisional Application 62270075 · Dec 21, 2015
Related Publication 20200270273A1 · Aug 27, 2020