Medicinal inhalers

1. A medicinal inhaler comprising:

a housing;

an air flow path defined by at least partially the housing and including an air inlet and an air outlet;

a flow governor positioned in the air flow path between the air inlet and the air outlet to govern air flow in the air flow path to a governing volumetric flow rate;

a breath-actuated dose release firing system located in the housing, wherein the firing system is configured to release a dose of medicament at a firing volumetric flow rate less than the governing volumetric flow rate; and

an inspiratory air flow detection system configured to detect an inspiratory air flow rate in the air flow path and to send an electrical signal to the firing system to fire when the inspiratory air flow rate is equal to at least the firing volumetric flow rate, wherein the inspiratory air flow detection system comprises a pressure sensor located in the air flow path upstream of the flow governor and downstream of the air inlet, and wherein the inspiratory air flow detection system further comprises a controller connected to the pressure sensor and the breath-actuated dose release firing system.

2. The inhaler of claim 1 , wherein the medicinal inhaler includes a pressurized metered dose inhaler (pMDI).

3. The inhaler of claim 1 , wherein the firing system includes a plunger movable between a first position and a second position to actuate a dose release valve.

4. The inhaler of claim 3 , wherein the plunger is configured to be operatively coupled to a medicament canister comprising the dose release valve.

5. The inhaler of claim 3 , wherein the firing system further includes a stored energy device configured to drive the plunger from the first position to the second position when stored energy in the stored energy device is released.

6. The inhaler of claim 3 , wherein the stored energy device includes a biasing element.

7. The inhaler of claim 3 , wherein the stored energy is triggered to release by a trigger connected to the inspiratory air flow detection system.

8. The inhaler of claim 3 , wherein the firing system further includes:

a guideway, wherein at least a portion of the guideway has a helical shape, the guideway having a first portion having a first helix angle with respect to the axis that is greater than zero, and a second portion having a second helix angle with respect to the axis, wherein the second helix angle is less than the first helix angle; and

a projection dimensioned to be received in the guideway, the projection being movable in the guideway, such that the projection and the guideway are movable with respect to one another between a first position corresponding to the first position of the plunger and a second position corresponding to the second position of the plunger, such that the projection is configured to be cammed along the guideway when the stored energy device drives the plunger to move between the first position and the second position;

wherein the guideway or the projection is fixedly coupled to the plunger.

9. The inhaler of claim 1 , further comprising a second pressure sensor located in the air flow path downstream of the flow governor.

10. The inhaler of claim 9 , wherein the pressure sensor upstream of the flow governor is located in a first conduit connected to the air flow path at a first location and the second pressure sensor is located in a second conduit connected to the air flow path at a second location downstream of the flow governor.

11. The inhaler of claim 10 , wherein the first conduit has a first cross-sectional area, the second conduit has a second cross-sectional area, and the air flow path has a third cross-sectional area, and wherein the ratio of the first cross-sectional area to the third cross-sectional area and the ratio of the second cross-sectional area to the third cross-sectional area are each no greater than 0.2.

12. The inhaler of claim 1 , wherein the flow governor includes:

a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; and

an internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly.

13. The inhaler of claim 12 , wherein at least a portion of the internal support structure is formed by the housing.