IP Library › Granted Patent US 10,772,949
Granted Patent B2
US 10,772,949 · App. 16/064,505 · Granted Sep 15, 2020

Dengue virus glycoprotein E DIII variants and uses thereof

Inventors: Jonathan R. Lai (Dobbs Ferry, NY); Margaret C. Kielian (Dobbs Ferry, NY); Julia C. Frei (Bronx, NY)
Assignee: Albert Einstein College of Medicine
A61K39/12A61P31/14C07K14/005C12N7/00A61K2039/55566C12N2770/24122C12N2770/24134Y02A50/386
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Quick Facts
Patent No.
US 10,772,949
App. No.
16/064,505
Granted
Sep 15, 2020
Kind
B2
Abstract

Specific Dengue virus glycoprotein subunit E DIII variants and their uses in preventing and treating Dengue virus infection are disclosed.

Claims (21)

1. A Dengue virus glycoprotein subunit E DIII variant comprising variant Ser27 (SEQ ID NO:1), variant SerD1 (SEQ ID NO:2), variant Ala1 (SEQ ID NO:3), variant Ala2 (SEQ ID NO:4), variant Ala3 (SEQ ID NO:5), variant Ala5 (SEQ ID NO:6), variant Ala11 (SEQ ID NO:7), or variant Ala30 (SEQ ID NO:8).

2. The variant of claim 1 consisting of Ser27 (SEQ ID NO:1).

3. The variant of claim 1 consisting of SerD1 (SEQ ID NO:2).

4. The variant of claim 1 consisting of Ala1 (SEQ ID NO:3).

5. The variant of claim 1 consisting of Ala2 (SEQ ID NO:4).

6. The variant of claim 1 consisting of Ala3 (SEQ ID NO:5).

7. The variant of claim 1 consisting of Ala5 (SEQ ID NO:6).

8. The variant of claim 1 consisting of Ala11 (SEQ ID NO:7).

9. The variant of claim 1 consisting of Ala30 (SEQ ID NO:8).

10. The variant of claim 2 , encoded by the nucleic acid set forth in SEQ ID NO:9.

11. The variant of claim 3 , encoded by the nucleic acid set forth in SEQ ID NO:10.

12. The variant of claim 4 , encoded by the nucleic acid set forth in SEQ ID NO:11.

13. The variant of claim 5 , encoded by the nucleic acid set forth in SEQ ID NO:12.

14. The variant of claim 6 , encoded by the nucleic acid set forth in SEQ ID NO:13.

15. The variant of claim 7 , encoded by the nucleic acid set forth in SEQ ID NO:14.

16. The variant of claim 8 , encoded by the nucleic acid set forth in SEQ ID NO:15.

17. The variant of claim 9 , encoded by the nucleic acid set forth in SEQ ID NO:16.

18. A dimer or oligomer comprising any of the variants of claim 1 .

19. A virion of an isolated, recombinant Dengue virus comprising a variant of claim 1 .

20. A Dengue virus composition comprising a variant of claim 1 .

21. The composition of claim 20 further comprising an immunological adjuvant.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 21, 2019
From: LAI, JONATHAN R.; KIELIAN, MARGARET; FREI, JULIA C.
To: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Reel/Frame 050775/0149 →
MERGER AND CHANGE OF NAME Recorded Feb 26, 2019
From: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.; ALBERT EINSTEIN COLLEGE OF MEDICINE
To: ALBERT EINSTEIN COLLEGE OF MEDICINE
Reel/Frame 048438/0275 →