Nicotine pouch
A pouch designed for administration of an active ingredient in the oral cavity is disclosed, the pouch containing a matrix composition including a combination of nicotine and a water-soluble composition.
1. A pouch designed for administration of an active ingredient in the oral cavity, the pouch containing a matrix composition comprising a water-insoluble composition, and granules consisting of a combination of nicotine and a water-soluble composition, wherein the water-soluble composition comprises sugar alcohol as a water-soluble carrier for the nicotine, and wherein the water-insoluble composition comprises microcrystalline cellulose.
2. The pouch according to claim 1 , wherein said nicotine is provided as a complex between nicotine and an ion exchange resin.
3. The pouch according to claim 2 , wherein said complex between nicotine and the ion exchange resin is nicotine polacrilex resin (NPR).
4. The pouch according to claim 1 , wherein the nicotine is provided as a salt.
5. The pouch according to claim 1 , wherein the nicotine is provided as its base form.
6. The pouch according to claim 1 , wherein the water-soluble composition is a powder composition.
7. The pouch according to claim 1 , wherein the matrix composition comprises a pH controlling agent.
8. The pouch according to claim 7 , wherein the pH controlling agent is a buffering agent.
9. The pouch according to claim 7 , wherein the pH controlling agent is a basic pH controlling agent.
10. The pouch according to claim 1 , wherein the matrix composition comprises a release controlling composition.
11. The pouch according to claim 10 , wherein the release controlling composition is hydrophobic.
12. The pouch according to claim 10 , wherein said release controlling composition comprises one or more metallic stearates.
13. The pouch according to claim 10 , wherein the matrix composition comprises said release controlling composition in an amount of between 1 and 20 percent by weight of said matrix composition.
14. The pouch according to claim 10 , wherein said matrix composition comprises a first portion and a second portion, wherein said first and second portions have different contents of said release controlling composition.
15. The pouch according to claim 14 , wherein both of said first and second portions comprises nicotine.
16. The pouch according to claim 15 , wherein the pouch comprises a water-permeable membrane.
17. The pouch according to claim 15 , wherein said matrix composition comprises nicotine in an amount of 0.1 to 30 percent by weight of said matrix composition.
18. The pouch according to claim 15 , wherein the pouch comprises a humectant.
19. The pouch according to claim 15 , wherein the pouch is free of tobacco.
20. A pouch designed for administration of an active ingredient in the oral cavity, the pouch containing a matrix composition comprising a water-insoluble composition, and granules consisting of a combination of nicotine and a water-soluble composition, wherein the water-soluble composition comprises sugar alcohol as a water-soluble carrier for the nicotine, wherein the nicotine is not provided as a nicotine salt, and wherein the water-insoluble composition comprises microcrystalline cellulose.
21. The pouch according to claim 18 , wherein the humectant is selected from the group consisting of sugar alcohols, alginate, cellulose, microcrystalline cellulose, pectin, xanthan gum, and combinations thereof.