System and method for treating various neurological disorders using synchronized nerve activation
A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.
1. Neuromodulation system for treatment of physiological disorders comprising:
at least one stimulator for stimulating a cranial nerve;
at least one detector configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the at least one stimulator so that it is synchronized with the at least one predetermined physiological state detected by the at least one detector,
wherein the predetermined physiological state is rapid eye movement (REM) sleep and the at least one stimulator provides stimulation only during the REM sleep.
2. The system according to claim 1 wherein the at least one stimulator is configured to provide stimulation that is synchronized with the REM sleep so as to provide treatment of Alzheimer's disease.
3. The system according to claim 1 wherein the cranial nerve stimulated is the vagus nerve.
4. The system according to claim 3 wherein the vagus nerve is the auricular branch of the vagus nerve.
5. The system according to claim 4 wherein the at least one stimulator is a non-invasive stimulator positioned at a location selected from the group of locations consisting of: behind the ear (BTE) of a patient, in the ear (ITE) of a patient, in the ear canal (IEC) of a patient, and completely in the ear canal (CIC) of a patient.
6. The system according to claim 1 wherein the control unit is configured to provide a feedback mechanism that controls the at least one stimulator, and wherein the feedback mechanism is feedback based on a cognitive result.
7. The system according to claim 6 wherein the system includes a wired connection between the at least one detector, the control unit, a power supply and the at least one stimulator.
8. The system according claim 7 wherein the system includes a wireless connection to a remote control unit.
9. The system according to claim 8 wherein the at least one stimulator is at least two stimulation sites.
10. The system according to claim 9 wherein the at least two stimulation sites are each different stimulators each providing a different type of stimulation.
11. A method of neuromodulating a patient for treatment of physiological disorders comprising the steps of:
detecting a predetermined physiological state; and
applying stimulation to a cranial nerve during the predetermined physiological state by at least one stimulator of a neuromodulation system,
wherein the physiological state is a rapid eye movement (REM) sleep.
12. A method according to claim 11 where the cranial nerve is the vagus nerve.
13. A method according to claim 12 where the cranial nerve is the auricular branch of the vagus nerve (ABVN).
14. A method according to claim 11 further comprising a step of placing at least one stimulator of the neuromodulation system onto a patient's ear for noninvasive stimulation of the ABVN.
15. The method according to claim 11 wherein said neuromodulation is delivered for treatment of Alzheimer's disease.
16. The method according to claim 11 , further comprising a step of optimizing the at least one stimulator to provide stimulation for treatment of Alzheimer's disease.
17. The method of claim 11 wherein said step of applying the at least one stimulator is at least two stimulation sites.
18. The method of claim 17 wherein the at least two stimulation sites are different stimulators providing different types of stimulation.
19. Neuromodulation system for treatment of physiological disorders comprising:
at least one stimulator for stimulating a cranial nerve;
at least one detector configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the at least one stimulator so that it is synchronized with the at least one predetermined physiological state detected by the at least one detector,
wherein the predetermined physiological state is rapid eye movement (REM) sleep and at least one stimulator provides stimulation only during the REM sleep,
wherein the physiological disorder is Alzheimer's disease.