Systems for inhalation of therapeutic and diagnostic gas and methods of use thereof

1. A system configured to administer at least one therapeutic gas comprising nitric oxide to a patient, comprising:

a. at least one reservoir tube, having a proximal and a distal end, wherein the distal end is configured to be open to the ambient environment such that gas moves through the distal end unimpeded; wherein the at least one reservoir tube further comprises a sampling port; and wherein the at least one reservoir tube has a volume larger than the tidal volume of the patient breath;

b. at least one therapeutic gas inlet at the proximal end of the at least one reservoir tube, wherein a delivery tube is connected to the at least one therapeutic gas inlet and at least one therapeutic gas source; and

c. a patient interface fluidly connected to the proximal end of the at least one reservoir tube via an inhalation check valve, wherein the sample port is distal to the inhalation check valve,

wherein the patient interface is configured to form a gas-tight seal between the patient and the system,

wherein the inhalation check valve is configured to be closed when the patient is exhaling,

wherein the at least one therapeutic gas is introduced into the at least one reservoir tube at the proximal end through the at least one therapeutic gas inlet at a time average flow rate greater than the time averaged inhalation rate of the patient, and the at least one therapeutic gas flows along the at least one reservoir tube, from the proximal end to the distal end whilst the patient is exhaling,

wherein the volume of the at least one therapeutic gas that is introduced into the at least one reservoir tube whilst the patient is exhaling, is greater than the patient's inhaled tidal volume, and

wherein the inhalation check valve is configured to be open when the patient is inhaling, and

wherein the inhalation check valve is configured to allow the at least one therapeutic gas to be administered to the patient.

2. The system of claim 1 , further comprising a second check valve, wherein the second check valve is configured to be closed whilst the patient is inhaling, and open whilst the patient is exhaling, and the system is configured to allow the second check valve to vent the gas exhaled by the patient.

3. The system of claim 1 , wherein the at least one reservoir tube is further configured to minimize the effort required by the patient to inhale.

4. The system of claim 1 , further comprising an exhaust port; wherein the diameter of the exhaust port is configured to minimize the effort required by the patient to exhale.

5. The system of claim 1 , wherein the system is configured to monitor the flow of gas through the proximal end of the at least one reservoir tube.

6. The system of claim 1 , wherein the system is configured to monitor at least one parameter of the flow of gas through the proximal end of the at least one reservoir tube, wherein the at least one parameter comprises: concentration, flow, contamination, or any combination thereof.

7. The system of claim 1 , wherein the at least one reservoir tube further comprises a flow meter at the distal end.

8. The system of claim 1 , wherein the sampling port is at the proximal end of the at least one reservoir tube.

9. The system of claim 1 , wherein the sampling port is configured to:

monitor the gas delivered to the patient and/or characterize the gas delivered to the patient.

10. The system of claim 9 , wherein the gas is characterized by content, contamination, flow, concentration, or any combination thereof.

11. The system of claim 1 , wherein the system is further configured to issue an alert if a monitored value of any one of the concentration the at least one therapeutic gas, flow rate, or any combination thereof, deviates from a threshold value.

12. The system of claim 1 , wherein the system is further configured to alter the flow rate, the concentration of the at least one therapeutic gas, or any combination thereof.

13. The system of claim 1 ,

wherein the at least one therapeutic gas is selected from the group consisting of: nitric oxide, helium, carbon dioxide, hypoxic gas, a diagnostic gas, or any combination thereof.

14. The system of claim 13 , wherein the at least one therapeutic gas is nitric oxide.

15. The system of claim 14 , wherein the concentration of nitric oxide is 160 ppm in a mixture of oxygen and nitrogen.

16. The system of claim 15 , wherein the nitric oxide is at a concentration of 400 ppm to 0.5 ppm.

17. The system of claim 1 , wherein the at least one therapeutic gas is a tracer gas.