Device and system for restricting fluid flow in physiological vessels
Provided is a device and system for restricting fluid flow in physiological vessels of humans or animals, the device being configurable in a first mode to be passively propellable by fluid flow within a physiological vessel and in a second mode to at least partially occlude a physiological vessel, the device having a first cross-sectional size in the first mode and a second cross-sectional size in the second mode, wherein the second cross-sectional size is greater than the first cross-sectional size. The system has a plurality of the devices described above, a power source for powering the devices; and a controller having one or more processors for controlling the devices.
1. A device for restricting fluid flow in physiological vessels of humans or animals, the device being configurable in a first mode to be propellable within a physiological vessel and in a second mode to at least partially occlude a physiological vessel, the device having a first cross-sectional size in the first mode and a second cross-sectional size in the second mode, wherein the second cross-sectional size is greater than the first cross-sectional size, wherein the device is configurable in the first mode to be passively propellable by fluid flow within a physiological vessel and in the second mode to at least partially occlude a capillary and to have the second cross-sectional size in a range of about 7.7 μm to about 14.3 μm, said device comprising:
a main body; and
one or more extending elements that extend from the main body to increase the cross-sectional size of the device when activated.
2. The device of claim 1 , wherein the first cross-sectional size is in a range of about 2.8 μm to about 5.2 μm.
3. The device of claim 1 , wherein the main body has a parallelpiped shape, wherein the one or more extending elements extend from at least one face of the main body.
4. The device of claim 1 , comprising at least one of the following:
a micromotor for driving the one or more extending elements;
an optical sensor for initializing the device;
an on-board processor for collecting and processing data.
5. A device for restricting fluid flow in physiological vessels of humans or animals, the device being configurable in a first mode to be propellable within a physiological vessel and in a second mode to at least partially occlude a physiological vessel, the device having a first cross-sectional size in the first mode and a second cross-sectional size in the second mode, wherein the second cross-sectional size is greater than the first cross-sectional size, wherein the device is configurable in the first mode to be passively propellable by fluid flow within a physiological vessel and in the second mode to at least partially occlude a capillary and to have the second cross-sectional size in a range of about 7.7 μm to about 14.3 μm, said device further comprising a transmitter for verifying the location of the device in the humans or animals.
6. The device of claim 5 , wherein the transmitter comprises an ultrasonic transmitter.
7. A device for restricting fluid flow in physiological vessels of humans or animals, the device being configurable in a first mode to be propellable within a physiological vessel and in a second mode to at least partially occlude a physiological vessel, the device having a first cross-sectional size in the first mode and a second cross-sectional size in the second mode, wherein the second cross-sectional size is greater than the first cross-sectional size, wherein the device is configurable in the first mode to be passively propellable by fluid flow within a physiological vessel and in the second mode to at least partially occlude a capillary and to have the second cross-sectional size in a range of about 7.7 μm to about 14.3 μm, said device further comprising a coil for generating electrical power required to power the device from a magnetic field.
8. The device of claim 1 , A device for restricting fluid flow in physiological vessels of humans or animals, the device being configurable in a first mode to be propellable within a physiological vessel and in a second mode to at least partially occlude a physiological vessel, the device having a first cross-sectional size in the first mode and a second cross-sectional size in the second mode, wherein the second cross-sectional size is greater than the first cross-sectional size, wherein the device is configurable in the first mode to be passively propellable by fluid flow within a physiological vessel and in the second mode to at least partially occlude a capillary and to have the second cross-sectional size in a range of about 7.7 μm to about 14.3 μm, said device further comprising a radiation sensitive device to enable the device to be activated by ionizing electromagnetic radiation.
9. The device of claim 8 , wherein the radiation sensitive device comprises a diode or a photodiode.
10. The device of claim 8 , wherein the radiation sensitive device comprises a transistor or a metal-oxide-semiconductor field-effect transistor (MOSFET).
11. The device of claim 8 , wherein the radiation sensitive device is coated with a scintillating material.
12. A system for restricting fluid flow in physiological vessels of humans or animals, the system comprising:
a plurality of devices for restricting fluid flow in physiological vessels of humans or animals, each device being configurable in a first mode to be propellable within a physiological vessel and in a second mode to at least partially occlude a physiological vessel, each device having a first cross-sectional size in the first mode and a second cross-sectional size in the second mode, wherein the second cross-sectional size is greater than the first cross-sectional size, wherein each device is configurable in the first mode to be passively propellable by fluid flow within a physiological vessel and in the second mode to at least partially occlude a capillary and to have the second cross-sectional size in a range of about 7.7 μm to about 14.3 μm;
a power source for powering the plurality of devices; and
a controller comprising one or more processors for controlling the plurality of devices.
13. The system of claim 12 , wherein the power source comprises a magnetic flux generating mechanism for powering nanobots, comprising a plurality of electrically isolated electromagnets, wherein the plurality of devices are powered via a plurality of overlapping magnetic fields which are generated from the electrically isolated electromagnets.
14. The system of claim 12 , comprising an external beam radiation device for producing a beam of ionizing electromagnetic radiation to illuminate tissue in a target region.
15. The system of claim 12 , comprising a capillary tube network having fibre optics attached to a camera control unit so that the plurality of devices can be viewed while being activated before being injected into the humans or animals.
16. The system of claim 12 , comprising an ultrasonic detection matrix for detecting ultrasonic signals generated from within the humans or animals.
17. The system of claim 16 , wherein the ultrasonic detection matrix comprises:
a flexible substrate material; and
a plurality of ultrasonic detection assemblies (UDA) attached to the substrate material.
18. The system of claim 17 , wherein each UDA comprises a plurality of ultrasonic detection modules (UDM) for detecting ultrasonic signals emitted by nanobots, each UDM comprising a rigid column disposed on a plurality of piezo-electric sensors.
19. The system of claim 18 , wherein each ultrasonic detection assembly (UDA) comprises a plurality of UDMs arranged in an array, with the rigid column of each UDM being of different height to that of other UDMs.