Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments
The invention provides, inter alia, methods of reducing gastrointestinal immune related adverse events, such as colitis and diarrhea, in subjects undergoing an immune treatment, such as an immune oncology treatment, such as anti-CTLA4 antibody and anti-PD-1 antibody combination treatment for melanoma. In certain aspects, the methods encompass administering a therapeutically effective amount of a polypeptide that inhibits MAdCAM-integrin binding, such as an anti-α4β7 integrin antibody, such vedolizumab or a related antibody.
1. A method of treating a gastrointestinal immune-related adverse event (gi-irAE) in a human subject having advanced melanoma and undergoing an immune oncology treatment comprising treatment with ipilimumab and nivolumab, said method comprising administering four doses of a therapeutically effective amount of an anti-α4β7 integrin antibody to the human subject who has advanced melanoma, and is undergoing concurrent immune oncology treatment comprising treatment with ipilimumab and nivolumab, such that the gi-irAE is treated,
wherein the antibody is administered in response to symptoms of a gi-riAE which is Grade 3 or 4 diarrhea,
wherein the antibody comprises the complementarity determining regions (CDRs):
Light chain:
CDR1 SEQ ID NO:7
CDR2 SEQ ID NO:8 and
CDR3 SEQ ID NO:9; and
Heavy chain:
CDR1 SEQ ID NO:4
CDR2 SEQ ID NO:5 and
CDR3 SEQ ID NO:6, and
wherein the subject exhibits no significant reduction of efficacy of the immune oncology treatment after administration of the anti-α4β7 integrin antibody.
2. The method of claim 1 , wherein the anti-α4β7 integrin antibody comprises the heavy chain variable region of SEQ ID NO:1 and the light chain variable region of SEQ ID NO:2 or SEQ ID NO:3.
3. The method of claim 1 , wherein the anti-α4β7 integrin antibody is administered at a dose selected from the group consisting of 1.25 to 8.0 mg/kg, 1.25 to 4.25 mg/kg, 1.75 to 3.75 mg/kg, 2.25 to 3.25 mg/kg, 2.86 mg/kg, 5.0 to 8.0 mg/kg, 5.5 to 7.5 mg/kg, 6.0 to 7.0 mg/kg, and 6.43 mg/kg.
4. The method of claim 1 , wherein the anti-α4β7 integrin antibody is administered to achieve a serum concentration of about: 10 μg/ml, or more.
5. The method of claim 1 , wherein the anti-α4β7 integrin antibody is administered at a unit dose of about: 108, 150, 165, 200, 216, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750 mg, or more.
6. The method of claim 1 , wherein, following at least one administration of the anti-α4β7 integrin antibody
ipilimumab is administered every three weeks concurrently with nivolumab.
7. The method of claim 1 , wherein, relative to a suitable control undergoing an immune oncology treatment, but does not receive the anti-α4β7 integrin antibody, the subject exhibits one or more of: increased efficacy of the immune oncology treatment, reduced grade of gi-irAE, reduced duration of gi-irAE, or a combination thereof.
8. The method of claim 1 , wherein the anti-α4β7 integrin antibody is vedolizumab.
9. The method of claim 4 , wherein the serum concentration is about 11 μg/ml, 12 μg/ml, 13 μg/ml, 14 μg/ml, 15 μg/ml, 16 μg/ml, 17 μg/ml, 18 μg/ml, 19 μg/ml, 20 μg/ml, 25 μg/ml, 30 μg/ml, 35 μg/ml, 40 μg/ml, 45 μg/ml, 50 μg/ml, or more.
10. The method of claim 1 , wherein the melanoma is unresectable melanoma or metastatic melanoma.
11. The method of claim 1 , wherein the anti-α4β7 integrin antibody is administered by intravenous infusion at a dose of 200 mg or 450 mg at zero, two, four weeks and twelve weeks or thirteen weeks.
12. The method of claim 1 , wherein the anti-α4β7 integrin antibody is administered at least four times.