Medicine obtained by combining FXR agonist and ARB
The present invention provides an NASH therapeutic agent including: an FXR agonist, preferably obeticholic acid or a pharmaceutically acceptable salt thereof; and an ARB or a pharmaceutically acceptable salt thereof.
1. A pharmaceutical composition comprising a combination of obeticholic acid or a pharmaceutically acceptable salt thereof in the amount of 2 mg-100 mg and losartan or a pharmaceutically acceptable salt thereof in the amount of 5 mg-100 mg, wherein the obeticholic acid or pharmaceutically acceptable salt thereof and losartan or pharmaceutically acceptable salt thereof are the only active pharmaceutical ingredients present in the composition.
2. The pharmaceutical composition of claim 1 , comprising one or more pharmaceutically acceptable carriers or excipients.
3. The pharmaceutical composition of claim 1 , comprising obeticholic acid or a pharmaceutically acceptable salt thereof in the amount of 5 mg-50 mg.
4. The pharmaceutical composition of claim 1 , comprising losartan or a pharmaceutically acceptable salt thereof in the amount of 10 mg-50 mg.
5. The pharmaceutical composition of claim 1 , comprising obeticholic acid or a pharmaceutically acceptable salt thereof in the amount of 5 mg-50 mg and losartan or a pharmaceutically acceptable salt thereof in the amount of 10 mg-50 mg.