Use of thyroid beta-agonists
Methods useful for treating X-linked adrenoleukodystrophy are provided.
1. A method of therapeutic treatment for X-linked adrenoleukodystrophy, comprising administering to a subject a compound having the structure
or a salt, ester, or prodrug thereof.
2. The method of claim 1 , wherein the compound is
or a salt, ester, or prodrug thereof.
3. The method of claim 2 , wherein the compound is
4. The method of claim 1 , wherein the compound is
or a salt, ester, or prodrug thereof.
5. The method of claim 4 , wherein the compound is
6. The method of claim 1 , wherein the compound is administered at a dose of between about 1_mg and about 100 mg per day.
7. The method of claim 1 , wherein the compound is administered daily, every other day, or intermittently for three months followed by a period of time from about 2 months to about 1 week when the compound is not administered.
8. The method of claim 6 , wherein the compound is administered at a dose of between about 1_mg and about 50 mg per day.
9. The method of claim 8 , wherein the compound is administered at a dose of between about 1_mg and about 25 mg per day.
10. The method of claim 1 , wherein the compound is administered at a dose of 100 mg/day, 50 mg/day, 25 mg/day, 20 mg/day, 15 mg/day, 10 mg/day, 5 mg/day, or 1 mg/day.
11. The method of claim 10 , wherein the compound is administered at a dose of 5 mg/day, 10 mg/day, or 15 mg/day.
12. The method of claim 10 , wherein the compound is administered at a dose of 5 mg/day.
13. The method of claim 10 , wherein the compound is administered at a dose of 10 mg/day.
14. The method of claim 1 , wherein the compound is administered at a dose of between about 1 mg and about 100 mg every other day.
15. The method of claim 14 , wherein the compound is administered at a dose of between about 1 mg and about 50 mg every other day.
16. The method of claim 14 , wherein the compound is administered at a dose of between about 1 mg and about 25 mg every other day.
17. The method of claim 1 , wherein the compound is administered at a dose of 10 mg every other day or 15 mg every other day.
18. The method of claim 1 , wherein the compound is administered daily, every other day, or intermittently for three months followed by a period of time of one month when the thyroid hormone receptor beta agonist is not administered.
19. The method of claim 1 , wherein the compound is administered daily, every other day, or intermittently for three months followed by a period of time of 14 days when the thyroid hormone receptor beta agonist is not administered.
20. The method of claim 1 , wherein the compound is administered daily, every other day, or intermittently for two months followed by a period of time of one month when the thyroid hormone receptor beta agonist is not administered.