Active molecule delivery system comprising microcells
The present invention is directed to an active molecule delivery system comprising a plurality of microcells wherein each of the microcells has a bottom, the panel has a first area and a second area, and the microcells in the first area have substantially the same bottom thickness and the microcells in the second area have added bottom thicknesses. Such a panel is useful for many applications, such drug administrations.
1. An active molecule delivery system comprising a plurality of microcells, wherein: each of the microcells has an opening and a bottom, the active delivery system has a first area and a second area, the microcells in the first area have substantially the same bottom thickness, and the microcells in the second area have thicker bottom than the microcells in the first area, and the openings of the microcells is spanned by a porous diffusion layer.
2. The active molecule delivery system of claim 1 , wherein the microcells in the second area have a bottom thickness which is 0.001 micron to 9/10 of the depth of the microcells in the first area, more than the bottom thickness of the microcells in the first area.
3. The active molecule delivery system of claim 1 , wherein the microcells in the second area have a bottom thickness which is 0.001 micron to ½ of the depth of the microcells in the first area, more than the bottom thickness of the microcells in the first area.
4. The active molecule delivery system of claim 1 , wherein the bottom thicknesses of the microcells in the second area are not the same.
5. A method for preparing an active molecule delivery system of claim 1 , comprising:
a) providing microcells;
b) filling the microcells in a pre-determined area, with a chemical composition containing a solid material dissolved or dispersed in a solvent;
c) removing the solvent; and
d) optionally curing the chemical composition after removal of the solvent.
6. The method of claim 5 , wherein the solvent is methyl ethyl ketone, acetone, or isopropyl alcohol.
7. The method of claim 5 , wherein the microcells are filled with different concentrations of the solid material in the chemical compositions.
8. The method of claim 7 , wherein the concentrations of the solid material in the chemical compositions are in the range of 0.01% to 90% by weight.
9. The method of claim 7 , wherein the concentrations of the solid material in the chemical compositions are in the range of 0.01% to 50% by weight.
10. The method of claim 5 , wherein the chemical composition is not the same as a composition from which the microcells are formed.
11. The method of claim 5 , wherein the chemical composition is the same as a composition from which the microcells are formed.
12. The active molecule delivery system of claim 1 , wherein the openings of the microcells in the first area and the second area have substantial the same surface area.