3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.
1. A compound of Formula I or a pharmaceutically acceptable salt thereof, including an enantiomer, a diastereoisomer, a tautomer thereof:
wherein
R 1 is
C 1-10 alkyl optionally substituted with at least one group selected from OR 6 , —CO 2 R 6 , and halo;
R 2 is hydrogen;
R 3 is
6 to 12 membered aryl optionally substituted with at least one group selected from C 1-6 alkyl, halo, and OR 6 ;
R 4 is —SO 2 NR 6 R 7 ;
R 5 is halo; and
R 6 and R 7 are independently selected from hydrogen and C 1-6 alkyl.
2. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein R 1 is C 1-10 alkyl substituted with at least one group selected from OR 6 , halo, and —CO 2 R 6 .
3. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein R 6 is hydrogen.
4. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein the moiety:
is of the form:
5. The compound or a pharmaceutically acceptable salt thereof of any one of claim 1 , wherein the moiety:
is of the form:
6. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.