SONODYNAMIC THERAPY
The present disclosure provides methods for treating diseased cells in a subject using sonodynamic therapy (SDT), comprising: administering to the subject a sonosensitizer composition comprising IRDye® 700DX, wherein the sonosensitizer composition associates with the diseased cell; and thereafter applying an ultrasonic wave to the diseased cell.
1 . A method for treating a diseased cell in a subject using sonodynamic therapy, said method comprising:
administering to the subject a sonosensitizer composition comprising IRDye® 700DX, wherein the sonosensitizer associates with the diseased cell; and
applying an ultrasonic wave to the diseased cell.
2 . The method of claim 1 , wherein said diseased cell is a cancer cell.
3 . The method of claim 2 , wherein said cancer cell is a cell of a solid tumor.
4 . The method of claim 3 , wherein said solid tumor is a member selected from the group consisting of lung, breast, bladder, ovarian, pancreatic, skin, esophagus, stomach, liver, colon and prostate cancer.
5 . The method of claim 1 , wherein said sonosensitizer composition comprises a carrier moiety.
6 . The method of claim 5 , wherein said carrier moiety is a virus-like particle.
7 . The method of claim 6 , wherein said virus-like particle comprises a L1 caspid protein, a L2 caspid protein or a combination thereof
8 . The method of claim 5 , wherein said carrier moiety is a nanotube.
9 . The method of claim 1 , wherein said sonosensitizer composition comprises a targeting agent.
10 . The method of claim 9 , wherein said targeting agent is an antibody.
11 . The method of claim 1 , wherein said administration comprises systemic administration to the subject, local administration to a tumor, or administration to a surgical site.
12 . The method of claim 1 , wherein said ultrasonic wave is applied at a frequency of about 0.1 MHz to about 30 MHz.
13 . The method of claim 12 , wherein said ultrasonic wave is applied at a frequency of about 1.0 MHz to about 5.0 MHz.
14 . The method of claim 12 , wherein said ultrasonic wave is applied at a frequency of about 1.0 MHz to about 2.0 MHz.
15 . The method of claim 1 , wherein said ultrasonic wave is applied at a power density of about 0.01 W/cm 2 to about 12 W/cm 2 .
16 . The method of claim 15 , wherein said ultrasonic wave is applied at a power density of about 1.0 W/cm 2 to about 6 W/cm 2 .
17 . The method of claim 15 , wherein said ultrasonic wave is applied at a power density of about 1.2 W/cm 2 to about 3.8 W/cm 2 .
18 . The method of claim 1 , wherein the ultrasonic wave is generated from an ultrasonic transducer applied locally.
19 . The method of claim 1 , wherein the ultrasonic transducer is appended to an endoscope.
20 . A kit, the kit comprising a sonosensitizer composition comprising IRDye® 700DX.