Composition for treating skin dermatoses
View Patent ↗Compositions including water, petrolatum, dimethicone, glycerrhetinic acid, at least one ceramide, at least one C2-C5 alkanol substituted with two to four hydroxyl groups, at least one N-acylethanolamine, and grape seed extract comprising proanthocyanidin, as well as methods of treating skin dermatoses and/or reducing symptoms associated with skin dermatoses using such compositions, are provided.
1. A composition comprising water, from about 1% to about 10% by weight of petrolatum, from about 1% to about 10% by weight of dimethicone, from about 0.1% to about 1% by weight of glycerrhetinic acid, from about 0.1% to about 1% by weight of at least one ceramide, from about 1% to about 20% by weight of at least one C2-C5 alkanol substituted with two to four hydroxyl groups, from about 0.001% to less than 1% by weight of at least one N-acylethanolamine, and from about 0.001% to less than 1% by weight of grape seed extract comprising proanthocyanidin, all weights being based on the total weight of the composition.
2. The composition of claim 1 , wherein the composition is free of film forming agents.
3. The composition of claim 1 , wherein the composition is free of homopolymers of polyvinylpyrrolidone.
4. The composition of claim 1 , wherein petrolatum and dimethicone are present in compositions of the present invention in a weight ratio of about 1:1.
5. The composition of claim 1 , wherein the composition comprises an occlusion component consisting essentially of petrolatum and dimethicone.
6. The composition of claim 1 , wherein the ceramide is ceramide PC-104.
7. The composition of claim 1 , wherein ceramide and glycerrhetinic acid are present in compositions of the present invention in a weight ratio of about 1:1.
8. The composition of claim 1 , wherein the composition comprises a stratum corneum water-holding-ability component consisting essentially of at least one ceramide.
9. The composition of claim 1 , wherein the composition comprises a C2-C5 alkanol substituted with two to four hydroxyl groups component consisting essentially of glycerol and propylene glycol in a weight ratio of from 4:1 to 3:1.
10. The composition of claim 1 , wherein the N-acylethanolamine is palmitamide MEA.
11. The composition of claim 1 , wherein the composition comprises an itch reduction component consisting essentially of palmitamide MEA.
12. The composition of claim 1 , wherein the composition comprises an inflammation reduction component consisting essentially of grape seed extract comprising proanthocyanidin, glycerrhetinic acid, and palmitamide MEA.
13. A composition consisting of:
Ingredient
Amount (wt %)
Thickening agent
0.6-0.8
Surfactant
7-9
Polyol humectant
7-8
Preservative
0.4-0.6
pH adjuster
0.75-1.25
Dimethicone
4-6
Petrolatum
4-6
Ceramide
0.4-0.6
N-acylethanolamine
0.008-0.03
Glycerrhetinic acid
0.3-0.5
Grape seed extract
0.05-0.2
Purified water
QS to 100.
14. A composition consisting of:
Ingredient
Amount (wt %)
Carbomer 980
About 0.7
Stearic acid
About 6.25
Glycerin
About 1.7
Propylene glycol
About 5.8
Polysorbate 20
About 1.4
Triethanolamine
About 1
Phenonip XB
About 0.5
Sodium hydroxide
About 0.008
Dimethicone
About 5
Petrolatum
About 5
Ceramid PC-104
About 0.5
Palmitamide MEA
About 0.01
Glycerrhetinic acid
About 0.4
Grape seed extract
About 0.1
Purified water
QS to 100.
15. A method of treating one or more skin dermatoses and/or reducing at least one symptom associated with one or more skin dermatoses comprising topically administering the composition of claim 1 to the one or more skin dermatoses in an amount sufficient to treat the one or more skin dermatoses and/or reduce at least one symptom associated with the one or more skin dermatoses.
16. A method of treating one or more skin dermatoses and/or reducing at least one symptom associated with one or more skin dermatoses comprising topically administering the composition of claim 13 to the one or more skin dermatoses in an amount sufficient to treat the one or more skin dermatoses and/or reduce at least one symptom associated with the one or more skin dermatoses.
17. A method of treating one or more skin dermatoses and/or reducing at least one symptom associated with one or more skin dermatoses comprising topically administering the composition of claim 14 to the one or more skin dermatoses in an amount sufficient to treat the one or more skin dermatoses and/or reduce at least one symptom associated with the one or more skin dermatoses.