Peptides and Their Use in The Treatment of Hair
Peptides, topical compositions, and methods of improving health and/or appearance of human integuments, such as keratinous surfaces and fibers are provided. The peptides have from 3-12 amino acid residues and comprise the sequence YNT (SEQ ID NO: 1) or PVG (SEQ ID NO: 2).
1 . A method for strengthening, thickening, and/or promoting growth of human keratin fibers comprising topically applying to skin in the area of keratin fiber follicles a composition comprising, in a physiologically acceptable vehicle, an active agent comprising a peptide having from 3-6 amino acid residues, comprising the sequence YNT (SEQ ID NO: 1) or PVG (SEQ ID NO: 2).
2 . The method according to claim 1 , wherein said active agent comprises the sequence YNT (SEQ ID NO: 1).
3 . The method according to claim 2 , wherein said active agent comprises the sequence PVG (SEQ ID NO: 2).
4 . The method according to claim 1 , wherein said active agent is peptide wherein said peptide is optionally functionalized with a C 2-24 hydrocarbon to improve lipophilicity.
5 . The method according to claim 4 , wherein said active agent is palmitoyl-(YNT).
6 . The method according to claim 4 , wherein said active agent is palmitoyl-(PVG).
7 . The method according to claim 2 , wherein said active agent is K-Ava-YNTK (SEQ ID NO: 3).
8 . The method according to claim 3 , wherein said active agent is K-Ava-PVGK (SEQ ID NO: 4).
9 . The method according to claim 1 , wherein said composition is applied at least once daily for at least four weeks.
10 . A composition comprising an active agent comprising a peptide having from 3-6 amino acid residues, comprising the sequence YNT (SEQ ID NO: 1) or PVG (SEQ ID NO: 2), and a physiologically acceptable vehicle, wherein the active agent is present in an amount from about 0.0001% to about 10% by weight of the composition.
11 . The composition according to claim 10 , wherein said active agent comprises the sequence YNT (SEQ ID NO: 1).
12 . The composition according to claim 10 , wherein said active agent comprises the sequence PVG (SEQ ID NO: 2).
13 . The composition according to claim 10 , wherein said active agent is peptide wherein said peptide is optionally functionalized with a C 2-24 hydrocarbon to improve lipophilicity.
14 . The composition according to claim 13 , wherein said active agent is palmitoyl-(YNT).
15 . The composition according to claim 13 , wherein said active agent is palmitoyl-(PVG).
16 . The composition according to claim 10 , wherein said active agent is K-Ava-YNTK (SEQ ID NO: 3).
17 . The composition according to claim 10 , wherein said active agent is K-Ava-PVGK (SEQ ID NO: 4).
18 . The cosmetic composition of claim 10 , wherein the active agent is present in an amount from about 0.001% to about 1% by weight of the composition.
19 . The composition of claim 10 , wherein said topically acceptable vehicle comprises a water-in-oil, oil-in-water, silicone-in-water, or water-in-silicone emulsion, further comprising an emulsifier.
20 . The composition of claim 10 , wherein said composition is in the form of a shampoo, conditioner, hair gel, mousse, tonic, or lotion.
21 . The composition of claim 10 , wherein said composition further includes one or more of creatine, a botanical extract from Pouzolzia pentandra, N-biotinyl-gly-his-lys, hydrolyzed wheat protein, saw palmetto (Serenoa) extract, Emblica officianalis extract, and beta-glycyrrhetic acid.