Ophthalmic compositions

1. An ophthalmic composition, comprising:

a.) a polymer mixture comprising

i. a cellulose derivative;

ii a tamarind seed extract; and

iii hyaluronic acid;

b.) a polyquaternium compound selected from polyquaternium-1, polyquaternium-10, polyquaternium-42 or mixtures;

c.) from 0.4% w/v to about 1.5% w/v of the total composition of a polyol and

d.) an aqueous component comprising greater than about 50% by weight, of the total composition, of water

wherein the total concentration of the polymer mixture of cellulose derivative, tamarind seed extract and hyaluronic acid is between greater than about 0.4% to about 0.9%, by weight, of the total composition and further wherein the cellulose derivative, tamarind seed extract and hyaluronic acid are combined at a ratio of: 1 to 10 parts cellulose derivative: 1 to 4 parts tamarind seed extract: 1 to 2 parts hyaluronic acid, to form the polymer mixture such that the composition has:

i. a viscosity of from about 30 to 100 cps at zero shear as measured by the AR2000 Flow Test Method; and

ii. a viscosity of less than 30 cps at a shear rate of blinking of 1/100 sec. as measured by the AR2000 Flow Test Method

and wherein the composition is formulated as a sterile aqueous solution.

2. The composition of claim 1 wherein the cellulose derivative is selected from (hydroxyalkyl cellulose polymers, alkyl hydroxyalkyl cellulose polymers; methyl cellulose; methyl cellulose derivatives; hydroxymethycellulose derivatives; and mixtures thereof.

3. The composition of claim 2 , wherein the hydroxyalkyl cellulose polymers are selected from hydroxyethyl cellulose, hydroxypropyl cellulose and mixtures thereof.

4. The composition of claim 2 , wherein the alkyl hydroxyalkyl cellulose polymers is cetyl hydroxyethyl cellulose.

5. The composition of claim 2 , wherein the methyl cellulose derivative is selected from carboxymethyl cellulose, hydroxymethyl cellulose, a hydroxymethyl cellulose derivative or mixtures thereof.

6. The composition of claim 5 , wherein the hydroxymethyl cellulose derivative is selected from hydroxypropyl methylcellulose, hydroxybutyl methyl cellulose or mixtures thereof.

7. The composition of claim 1 , wherein any non-ionic and anionic polymers in the composition are present at a the total concentration from about 0.4% to about 1.0%, by weight, of the total composition.

8. The composition of claim 1 , wherein the surface tension of the composition ranges from about 40.8 dynes/cm to 51.9 dynes/cm as measured by the Rame-Hart—DROPimage Advanced Software Pendant Drop Method.

9. The composition of claim 1 , wherein the rate of moisture loss for the composition is less than 1 mg/3 minutes at 37° C. and 70% relative humidity as measured by the DVS Intrinsic Measurement System and DVS-Intrinsic Control Software Method.

10. The composition of claim 1 , wherein the composition has an elastic modulus G′ greater than 0.70 (or about 0.70) Pascals and a phase angle δ of from about 40° to about 65° as measured by the Bohlin CVOR Rheometer Visco-Elastic Property Test Method.

11. The composition of claim 1 , wherein the composition has:

i. a surface tension ranging from about 40.8 dynes/cm to 51.9 dynes/cm as measured by the Rame-Hart—DROPimage Advanced Software Pendant Drop Method;

ii. a rate of moisture loss of less than 1 mg/3 minutes at 37° C. and 70% relative humidity as measured by the DVS Intrinsic Measurement System and DVS-Intrinsic Control Software Method;

iii. an elastic modulus G′ greater than 0.70 (or about 0.70) Pascals and a phase angle δ of from about 40° to about 65° as measured by the Bohlin CVOR Rheometer Visco-Elastic Property Test Method.