Treating cancer using a blautia strain
Provided herein are methods and compositions related to Blautia Strain A useful as therapeutic agents.
1. A method of inducing an anti-tumor immune response in a subject comprising orally administering to the subject an effective amount of a bacterial composition comprising Blautia Strain A (ATCC Deposit Number PTA-125134) wherein the subject has a tumor.
2. The method of claim 1 , wherein the tumor is a renal cell carcinoma, bladder cancer, prostate cancer, lung cancer, colon cancer, colorectal cancer, melanoma, breast cancer, pancreatic cancer or hepatocellular carcinoma tumor.
3. The method of claim 1 , wherein at least 50% of the bacteria in the bacterial composition are Blautia Strain A.
4. The method of claim 1 , wherein substantially all at least 99% of the bacteria in the bacterial composition are Blautia Strain A.
5. The method of claim 1 , wherein the bacterial composition comprises at least 1×10 6 colony forming units (CFUs) of Blautia Strain A.
6. The method of claim 1 , wherein the bacterial composition further comprises a pharmaceutically acceptable carrier.
7. The method of claim 1 , wherein the bacterial composition is formulated as a capsule or a tablet.
8. The method of claim 7 , wherein the capsule or tablet comprises an enteric coating.
9. The method of claim 8 , wherein at least 99% of the bacteria in the bacterial composition are Blautia Strain A.
10. The method of claim 9 , wherein the bacterial composition comprises at least 2×10 8 organisms of Blautia Strain A.
11. The method of claim 1 , wherein the bacterial composition comprises live bacteria, attenuated bacteria, or killed bacteria.
12. The method of claim 1 , wherein the method further comprises administering to the subject a second cancer therapy.
13. The method of claim 12 , wherein the second cancer therapy comprises the administration of a chemotherapy agent to the subject.
14. The method of claim 12 , wherein the second cancer therapy comprises administering an antibiotic to the subject.
15. The method of claim 1 , wherein the method further comprises administering a prebiotic to the subject.