Devices, systems and methods for medicament delivery
An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.
1. A method of delivering a medicament, comprising:
placing a distal end surface of a base of a medical injector into contact with a body, the medical injector including a housing, a medicament container within the housing, a plunger within the medicament container, a needle fluidically coupled to the medicament container, an energy storage member, a valve, and a flexible member coupled between the plunger and the valve; and
actuating the medical injector to cause the energy storage member to produce a pressurized gas within a gas chamber defined by the housing, the pressurized gas exerting a force to: A) move the needle from a first needle position, in which the needle is within the housing, to a second needle position, in which a portion of the needle is outside of the housing and B) move the plunger within the medicament container to convey the medicament from the medicament container via the needle,
the flexible member transitioning from a first configuration to a second configuration when the plunger moves within the medicament container, the flexible member actuating the valve to release the pressurized gas from the gas chamber when the flexible member is transitioned from the first configuration to the second configuration.
2. The method of claim 1 , wherein:
the medical injector is configured to cause the needle to move towards the first needle position after the pressurized gas is released from the gas chamber.
3. The method of claim 1 , wherein the actuating includes pressing the base against a target surface of the body to move the base relative to the housing.
4. The method of claim 1 , wherein a length of the flexible member increases when the flexible member transitions from the first configuration to the second configuration.
5. The method of claim 4 , wherein:
a proximal end portion of the flexible member is coupled to the valve; and
the length of the flexible member increases when the plunger moves within the medicament container, the proximal end portion of the flexible member actuating the valve when the plunger moves a predetermined distance within the medicament container.
6. The method of claim 5 , wherein the flexible member is one of a string, an elastic member or a biasing member.
7. The method of claim 6 , wherein:
a portion of the valve is within a vent opening defined by the housing to fluidically isolate the gas chamber from an external volume when the valve is in a first valve position, the proximal end portion of the flexible member moving the valve to a second valve position when the flexible member is transitioned to its second configuration, the gas chamber in fluid communication with the external volume via the vent opening when the valve is in the second valve position.
8. The method of claim 1 , wherein the medicament is any one of a drug or a biologic product.
9. The method of claim 1 , wherein the medicament is a biologic product containing at least one of a hormone or an antidote.
10. The method of claim 1 , wherein the medicament is epinephrine.
11. A method of delivering a medicament, comprising:
placing a distal end surface of a base of a medical injector into contact with a body, the medical injector including a housing, a medicament container within the housing, a movable member, a needle, an energy storage member, a valve, and an expandable assembly coupled between the movable member and the valve; and
actuating the medical injector to cause the energy storage member to produce a pressurized gas within a gas chamber defined by the housing, the pressurized gas exerting a force to: A) move the needle from a first needle position, in which the needle is within the housing, to a second needle position, in which a portion of the needle is outside of the housing and B) move the movable member within the medicament container to convey the medicament from the medicament container via the needle,
the expandable assembly transitioning from a first configuration to a second configuration when the movable member moves within the medicament container, the expandable assembly actuating the valve to release the pressurized gas from the gas chamber when the expandable assembly is transitioned from the first configuration to the second configuration.
12. The method of claim 11 , wherein:
the medical injector is configured to cause the needle to move towards the first needle position after the pressurized gas is released from the gas chamber.
13. The method of claim 12 , wherein a length of the expandable assembly increases when the expandable assembly transitions from the first configuration to the second configuration.
14. The method of claim 13 , wherein:
the length of the expandable assembly increases when the movable member moves within the medicament container, a proximal end portion of the expandable assembly actuating the valve when the movable member moves a predetermined distance within the medicament container.
15. The method of claim 12 , wherein the expandable assembly includes a flexible member.
16. The method of claim 15 , wherein the flexible member is one of a string, an elastic member or a biasing member.
17. The method of claim 12 , wherein:
a portion of the valve is within a vent opening defined by the housing to fluidically isolate the gas chamber from an external volume when the valve is in a first valve position, a proximal end portion of the expandable assembly moving the valve to a second valve position when the expandable assembly is transitioned to its second configuration, the gas chamber in fluid communication with the external volume via the vent opening when the valve is in the second valve position.