IP Library › Granted Patent US 11,040,034
Granted Patent B2
US 11,040,034 · App. 16/124,846 · Granted Jun 22, 2021

Metalloenzyme inhibitor compounds

Inventors: Steven Sparks (Apex, NC); Christopher M. Yates (Raleigh, NC); Sammy R. Shaver (Chapel Hill, NC); William J. Hoekstra (Durham, NC)
Assignee: PHASEBIO PHARMACEUTICALS, INC.
A61K31/501A61K31/4184A61K31/4188A61K31/437C07D401/14C07D403/04C07D403/14C07D405/14C07D417/14C07D471/04
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,040,034
App. No.
16/124,846
Granted
Jun 22, 2021
Kind
B2
Abstract

Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Claims (5)

1. A compound having a structure selected from the group consisting of:

2. A method of alleviating or abating hypertension or ameliorating a symptom thereof in a patient, comprising administering to the patient an effective amount of a compound having a structure selected from the group consisting of

3. The method of claim 2 , wherein the hypertension is resistant hypertension.

4. A method of inhibiting aldosterone synthase (CYP11B2) activity in a patient with hypertension comprising contacting a compound with a structure selected from the group consisting of

with aldosterone synthase (CYP11B2).

Assignments (14)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2026
From: CORXEL PHARMACEUTICALS HONG KONG LIMITED
To: CORXEL PHARMACEUTICALS LIMITED
Reel/Frame 073958/0018 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2026
From: CORXEL PHARMACEUTICALS LIMITED
To: CORXEL PHARMACEUTICALS, INC.
Reel/Frame 073958/0129 →
CHANGE OF NAME Recorded Mar 14, 2025
From: JI XING PHARMACEUTICALS HONG KONG LIMITED
To: CORXEL PHARMACEUTICALS HONG KONG LIMITED
Reel/Frame 070523/0516 →
CORRECTION OF ERROR IN ASSIGNEE ADDRESS AS LISTED IN COVER SHEET PREVIOUSLY RECORDED AT REEL/FRAME 062691/0373 Recorded Jun 6, 2023
From: PHASEBIO PHARMACEUTICALS, INC.
To: JI XING PHARMACEUTICALS HONG KONG LIMITED
Reel/Frame 063873/0889 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 14, 2023
From: PHASEBIO PHARMACEUTICALS, INC.
To: JI XING PHARMACEUTICALS HONG KONG LIMITED
Reel/Frame 062691/0373 →
RELEASE OF SECURITY INTEREST Recorded Jan 13, 2023
From: JMB CAPITAL PARTNERS LENDING, LLC
To: PHASEBIO PHARMACEUTICALS, INC.
Reel/Frame 062376/0850 →
SECURITY INTEREST Recorded Oct 31, 2022
From: PHASEBIO PHARMACEUTICALS, INC.
To: JMB CAPITAL PARTNERS LENDING, LLC
Reel/Frame 061601/0001 →
SECURITY INTEREST Recorded Oct 10, 2022
From: PHASEBIO PHARMACEUTICALS, INC.
To: JMB CAPITAL PARTNERS LENDING, LLC
Reel/Frame 061367/0674 →
PATENT AND TRADEMARK SECURITY AGREEMENT Recorded Nov 12, 2020
From: PHASEBIO PHARMACEUTICALS, INC.
To: SFJ PHARMACEUTICALS X, LTD.
Reel/Frame 054401/0188 →
SECURITY INTEREST Recorded Apr 21, 2020
From: PHASEBIO PHARMACEUTICALS, INC.
To: SILICON VALLEY BANK, AS AGENT
Reel/Frame 052456/0343 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 20, 2020
From: SELENITY THERAPEUTICS (BERMUDA), LTD.
To: PHASEBIO PHARMACEUTICALS, INC.
Reel/Frame 051878/0894 →
CHANGE OF NAME Recorded May 2, 2019
From: VIAMET PHARMACEUTICALS (BERMUDA), LTD.
To: SELENITY THERAPEUTICS (BERMUDA), LTD.
Reel/Frame 049074/0397 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 18, 2019
From: VIAMET PHARMACEUTICALS (NC), INC.
To: VIAMET PHARMACEUTICALS (BERMUDA), LTD.
Reel/Frame 048930/0527 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 18, 2019
From: SPARKS, STEVEN; YATES, CHRISTOPHER M.; SHAVER, SAMMY R.; HOEKSTRA, WILLIAM J.
To: VIAMET PHARMACEUTICALS (NC), INC.
Reel/Frame 048930/0474 →
Continuity (3)
Continuation 15857950 · Dec 29, 2017
Provisional Application 62440181 · Dec 29, 2016
Related Publication 20190008861A1 · Jan 10, 2019
Cited By (2)
US 12,358,893 US 12,458,642