Multi-arm polymeric prodrug conjugates of taxane-based compounds
Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.
1. A conjugate having a formula selected from the group consisting of
and
wherein each n is a positive integer from 10 to about 400, or pharmaceutically acceptable salts of each of the foregoing.
2. A composition comprising a plurality of conjugates, and a pharmaceutical excipient wherein at least 80% of the conjugates in the composition have the structure of the conjugates of claim 1 .
3. A method of treating a patient comprising:
administering the conjugate having the structure of the conjugates of claim 1 to a patient in need thereof.
4. A method of making the conjugate of claim 1 , comprising:
reacting, under conjugation conditions, a poly(ethylene glycol) reagent with a composition comprising a compound having the structure:
wherein R 1 , R 2 , and R 3 are the structures as set forth in claim 1 .