Reduced foaming vaccine compositions

1. A process for reducing the foaming of a solid vaccine composition when mixed with a liquid diluent, comprising adding an effective amount of a foam controlling agent to a solid composition susceptible to foaming comprising at least one anhydrous antigenic component, a stabilizer and an effervescent agent, whereby the solid vaccine composition is produced;

wherein the foam controlling agent is a sugar alcohol, and the effective amount of sugar alcohol is about 15% to 40% by weight of the solid vaccine composition, and upon adding a diluent to the solid vaccine composition, the effervescent agent reacts to form gas in situ, and foam resulting from the gas is reduced.

2. The process according to claim 1 , wherein the process further comprises: compressing the solid vaccine composition to form a compressed vaccine composition.

3. The process according to claim 1 , wherein the at least one anhydrous antigenic component is lyophilized or dried.

4. The process according to claim 1 , wherein the stabilizer comprises one or more amino acid or salts thereof, protein or salts thereof, albumin, gelatin, or combinations thereof.

5. The process according to claim 1 , wherein the at least one anhydrous antigenic component is newcastle disease virus, infectious bronchitis virus, fowl pox virus, avian encephalomyelitis virus, marek's disease virus, trichophyton verrucosum , avian paramyxovirus, mycobacterium paratuberculosis, meleagrid herpesvirus, orf virus, or sheep pox virus.

6. The process according to claim 1 , wherein the at least one anhydrous antigenic component is newcastle disease virus or infectious bronchitis virus.

7. The process according to claim 1 , wherein the process further comprises combining the composition with water, wherein upon dissolution of the composition, an effervescent reaction occurs and gas is formed in situ.

8. The process according to claim 1 , wherein the composition comprises a pair of effervescent agents.

9. The process according to claim 8 , wherein the pair of effervescent agents comprises a salt and an acid.

10. The process according to claim 9 , wherein the acid is citric acid, tartaric acid, malic acid, fumaric acid, adipic acid, succinic acid, acid anhydrides or mixtures thereof.

11. The process according to claim 9 , wherein the salt is carbonate salts, bicarbonate salts, sesquicarbonate salts, or mixtures thereof.

12. The process according to claim 1 , wherein the effective amount of sugar alcohol is about 33% to 40% by weight of the composition.

13. The process according to claim 1 , wherein the effective amount of sugar alcohol is about 26% to 35% by weight of the composition.

14. The process according to claim 1 , wherein the effective amount of sugar alcohol is about 25% to 33% by weight of the composition.

15. The process according to claim 1 , wherein the effective amount of sugar alcohol is about 25% to 40% by weight of the composition.

16. The process according to claim 1 , wherein the at least one anhydrous antigenic component is about 20% to about 50% by weight of the composition.

17. The process according to claim 1 , wherein at least one anhydrous antigenic component is up about 20% to about 40% by weight of the composition.

18. The process according to claim 7 , wherein the solid vaccine composition is characterized by complete dissolution in about 60 to 700 seconds upon contact with the water.

19. The process according to claim 7 , wherein the solid vaccine composition is characterized by complete dissolution in about 60 and to 300 seconds upon contact with the water.

20. The process according to claim 1 , wherein the foaming of the solid vaccine composition is reduced relative to the foaming of the composition in the absence of the sugar alcohol.

21. The process according to claim 1 , wherein the sugar alcohol is xylitol, mannitol, sorbitol or a mixture thereof.