IP Library Granted Patent US 10,463,468
Granted Patent B2
US 10,463,468 · App. 16/126,627 · Granted Nov 5, 2019

Thrombus aspiration with different intensity levels

Inventors: Vallabh Janardhan (Dallas, TX); Vikram Janardhan (Sacramento, CA)
Assignee: Insera Therapeutics, Inc.
A61F2/01A61B17/12109A61B17/12113A61B17/12122A61B17/12172A61B17/22A61B17/221A61B17/22031A61B17/22032A61B17/3207A61B17/32056A61B90/39A61F2/013A61M1/008A61M1/0031A61M25/0023A61M25/10A61M29/00B23K26/083B23K26/14B23K26/142B23K26/146B23K26/1435B23K26/20B23K26/38B26F3/004D04C1/06D04C3/48A61B2017/00526A61B2017/00592A61B2017/00606A61B2017/00641A61B2017/22001A61B2017/22002A61B2017/22034A61B2017/22035A61B2017/22067A61B2090/3966A61F2002/016A61F2002/018A61F2210/0014A61M2025/0042A61M2025/0681A61M2202/06A61M2207/10A61M2210/12D10B2509/06Y10T29/49913Y10T29/49995Y10T82/2521Y10T137/8376Y10T137/85954Y10T156/10
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Quick Facts
Patent No.
US 10,463,468
App. No.
16/126,627
Granted
Nov 5, 2019
Kind
B2
Abstract

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measurable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

Claims (50)

1. A system for facilitating aspiration of a thrombus in a vessel, the system comprising:

an automated motor pump configured to facilitate aspiration of the thrombus, the automated motor pump comprising an external control panel configured to receive input from an operator; and

power electronics that power and control the automated motor pump to generate a plurality of stored suction patterns having a plurality of intensity levels,

wherein the plurality of intensity levels comprises:

a first intensity level having a first negative pressure between 100 and 350 mm Hg;

a second intensity level having a second negative pressure between 351 and 550 mm Hg; and

a third intensity level having a third negative pressure between 551 and 769 mm Hg; and

wherein a first crescendo suction pattern of the plurality of stored suction patterns comprises a repetitive cycle comprising the first intensity level for a first duration, the second intensity level for a second duration after the first duration, and the third intensity level for a third duration after the second duration.

2. The system of claim 1 :

wherein the first duration, the second duration, and the third duration are each between 1 and 30 seconds; and

wherein a total duration of the repetitive cycle of the first crescendo suction pattern is between 1 minute and 15 minutes.

3. The system of claim 1 , wherein the first crescendo suction pattern is selectable by the operator from the plurality of stored suction patterns using the external control panel.

4. The system of claim 1 , further comprising a pause for a pause duration after the third duration, and wherein the pause duration is between 1 and 15 seconds.

5. The system of claim 1 , wherein at least one of the first, second, or third durations is different than another of the first, second, and third durations.

6. The system of claim 1 , wherein the first duration, the second duration, and the third duration are uniform.

7. A system for facilitating aspiration of a thrombus in a vessel, the system comprising:

a pump configured to facilitate aspiration of the thrombus; and

power electronics configured to power and control the pump to generate a plurality of stored suction patterns having a plurality of intensity levels,

wherein the plurality of intensity levels comprises:

a first intensity level having a first negative pressure;

a second intensity level having a second negative pressure, the second negative pressure being more negative than the first negative pressure; and

a third intensity level having a third negative pressure, the third negative pressure being more negative than the second negative pressure; and

wherein a first crescendo suction pattern of the plurality of stored suction patterns comprises the first intensity level for a first duration, the second intensity level for a second duration after the first duration, and the third intensity level for a third duration after the second duration.

8. The system of claim 7 ,

wherein the first crescendo suction pattern is selectable by an operator from the plurality of stored suction patterns using an external control panel communicatively coupled to the power electronics;

wherein the first duration, the second duration, and the third duration are each between 1 and 30 seconds;

wherein there is a pause for a pause duration after the third duration,

wherein the pause duration is between 1 and 15 seconds; and

wherein a total duration of the first crescendo suction pattern is between 1 minute and 15 minutes.

9. The system of claim 7 , wherein the first negative pressure is between 100 and 350 mm Hg, wherein the second negative pressure is between 351 and 550 mm Hg, and wherein the third negative pressure is between 551 and 769 mm Hg.

10. The system of claim 7 , wherein the first crescendo suction pattern is selectable by an operator from the plurality of stored suction patterns using an external control panel communicatively coupled to the power electronics.

11. The system of claim 10 , wherein the plurality of stored suction patterns comprises at least one of: a plurality of crescendo suction patterns comprising the first crescendo suction pattern and a second crescendo suction pattern, a plurality of diminuendo suction patterns, or a combination of both crescendo and diminuendo suction patterns.

12. The system of claim 7 , wherein the first crescendo suction comprises a repetitive cycle.

13. A system for facilitating aspiration of a thrombus in a vessel, the system comprising:

a pump that facilitates aspiration of the thrombus and generates a plurality of different stored suction patterns, wherein each suction pattern of the plurality of different stored suction patterns comprises a plurality of intensity levels,

wherein the plurality of intensity levels comprises:

a first intensity level having a first negative pressure;

a second intensity level having a second negative pressure, the second negative pressure being larger than the first negative pressure; and

a third intensity level having a third negative pressure, the third negative pressure being larger than the second negative pressure; and

wherein a first suction pattern of the plurality of different stored suction patterns comprises the first intensity level for a first duration, the second intensity level for a second duration, and the third intensity level for a third duration.

14. The system of claim 13 :

wherein at least some suction patterns of the plurality of different stored suction patterns are selectable by an operator from the plurality of different stored suction patterns using an external control panel,

wherein the first duration, the second duration, and the third duration are each between 1 and 30 seconds; and

wherein a total duration of the first suction pattern is between 1 minute and 15 minutes.

15. The system of claim 13 , wherein the first negative pressure is between 100 and 350 mm Hg, wherein the second negative pressure is between 351 and 550 mm Hg, and wherein the third negative pressure is between 551 and 769 mm Hg.

16. The system of claim 13 , wherein at least some of the plurality of different stored suction patterns are selectable by an operator from the plurality of different suction patterns using an external control panel.

17. The system of claim 13 , wherein the plurality of different stored suction patterns comprises at least one of: a plurality of crescendo suction patterns comprising a first crescendo suction pattern and a second crescendo suction pattern, a plurality of diminuendo suction patterns, or a combination of both crescendo and diminuendo suction patterns.

18. The system of claim 13 , wherein the first suction pattern comprises a repetitive cycle.

19. The system of claim 13 , wherein at least one of the first, second, or third durations is different than another of the first, second, and third durations.

20. The system of claim 13 , wherein the first duration, the second duration, and the third duration are uniform.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Sep 9, 2021
From: KNOBBE, MARTENS, OLSON & BEAR, LLP
To: INSERA THERAPEUTICS, INC.
Reel/Frame 057454/0677 →
SECURITY INTEREST Recorded Jun 30, 2020
From: INSERA THERAPEUTICS, INC.
To: KNOBBE, MARTENS, OLSON & BEAR, LLP
Reel/Frame 053095/0350 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2018
From: JANARDHAN, VALLABH; JANARDHAN, VIKRAM
To: INSERA THERAPEUTICS, INC.
Reel/Frame 046904/0323 →
Continuity (6)
Continuation 15903587 · Feb 23, 2018
Continuation 15085083 · Mar 30, 2016
Continuation 14848079 · Sep 8, 2015
Continuation PCTUS2014022843 · Mar 10, 2014
Continuation In Part 13953540 · Jul 29, 2013
Related Publication 20190008626A1 · Jan 10, 2019
Cited By (8)
US 12,220,139 US 12,262,903 US 12,343,024 US 12,376,908 US 12,478,390 US 12,575,844 US 12,642,542 US 12,642,543