Placental tissue composition for for treating cardiac tissue damage
Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
1. A composition for treating damaged cardiac tissue, said composition comprising dehydrated, cleaned, and disinfected placental tissue configured for non-obstructive placement to an area approximate to a damaged cardiac tissue in an amount sufficient to reduce damage and induce healing;
said placental tissue comprising a dehydrated amnion and a dehydrated chorion, said dehydrated amnion having an epithelial cell layer and/or a fibroblast layer; and
wherein said composition is in the form of a patch; is in an injectable form; or is micronized.
2. The composition of claim 1 , wherein the dehydrated, cleaned, and disinfected placental tissue retains an effective amount of stem cell recruiting factors, growth factors, and/or angiogenesis inducing factors.
3. The composition of claim 1 , wherein the dehydrated, cleaned, and disinfected placental tissue comprises one or more of PDGF-AA, PDGF-BB, TGFa, TGFB, bFGF, EGF, VEGF, IL-10, IL-4, P1GF, TIMP-1, TIMP-2, and TIMP-4.
4. The composition of claim 1 , which is a patch.
5. The composition of claim 1 , wherein the dehydrated, cleaned, and disinfected placental tissue is micronized.
6. The composition of claim 1 , which is in an injectable form.