Biomedical patches with aligned fibers
A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.
1. A fiber structure for repairing a void in a biological tissue, the fiber structure defining a center, an inner area extending from the center to an inner perimeter, and an outer area extending from the inner perimeter to an outer perimeter, wherein the inner area and the outer area at least partially overlap, the fiber structure comprising a first plurality of radially aligned polymeric fibers extending from the center to the inner perimeter, and a second plurality of radially aligned polymeric fibers extending from the inner perimeter to the outer perimeter;
wherein a spatial fiber density of the inner area is substantially the same as a spatial fiber density of the outer area.
2. The fiber structure of claim 1 , wherein the structure defines a circular perimeter about the center.
3. The fiber structure of claim 2 , wherein the circular perimeter defines a diameter of between one centimeter and ten centimeters.
4. The fiber structure of claim 1 , wherein the fiber structure defines a single layer comprising the first and second plurality of radially aligned polymeric fibers, and a plurality of non-radially aligned polymeric fibers.
5. The fiber structure of claim 1 , wherein the first and second plurality of radially aligned polymeric fibers define a first layer, the fiber structure further comprising a second layer including a plurality of non-radially aligned polymeric fibers.
6. The fiber structure of claim 5 , wherein the second layer comprises a plurality of uniaxially aligned polymeric fibers.
7. The fiber structure of claim 5 , wherein the second layer comprises a plurality of randomly oriented polymeric fibers.
8. The fiber structure of claim 1 , wherein the first and second plurality of polymeric fibers are solid polymeric fibers.
9. The fiber structure of claim 8 , wherein the solid polymeric fibers further comprise a substance, the substance including one or more of a growth factor, a protein, a drug, and a chemotherapeutic agent.
10. The fiber structure of claim 1 , wherein the first and second plurality of polymeric fibers are degradable.
11. A fiber structure for repairing a void in a biological tissue, the fiber structure defining a center, an inner area extending from the center to an inner perimeter, and an outer area extending from the inner perimeter to an outer perimeter, wherein the inner area and the outer area at least partially overlap, the fiber structure comprising a first plurality of radially aligned hollow polymeric fibers extending from the center to the inner perimeter, and a second plurality of radially aligned hollow polymeric fibers extending from the inner perimeter to the outer perimeter;
wherein a spatial fiber density of the inner area is substantially the same as a spatial fiber density of the outer area.
12. The fiber structure of claim 11 , wherein each of the first and second plurality of hollow fibers defines a cavity within which a substance is deposited.
13. The fiber structure of claim 12 , wherein the deposited substance includes one more of a growth factor, a protein, a drug, and a chemotherapeutic agent.
14. The fiber structure of claim 11 , wherein the first and second plurality of hollow polymeric fibers are porous.
15. The fiber structure of claim 11 , wherein the first and second plurality of hollow polymeric fibers are degradable.
16. The fiber structure of claim 11 , wherein the fiber structure defines a single layer comprising the first and second plurality of radially aligned hollow polymeric fibers and a plurality of non-radially aligned polymeric fibers.
17. The fiber structure of claim 11 , wherein the first and second plurality of radially aligned hollow polymeric fibers defines a first layer, the fiber structure further comprising a second layer including a plurality of non-radially aligned polymeric fibers.
18. The fiber structure of claim 17 , wherein the second layer comprises a plurality of uniaxially aligned polymeric fibers or a plurality of randomly oriented polymeric fibers.