IP Library › Patent Application 16130860
Patent Application
App. No. 16/130,860

BUCCAL, POLAR AND NON-POLAR SPRAY CONTAINING ZOLIPIDEM

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Quick Facts
Patent No.
US None
App. No.
16/130,860
Abstract

Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide zolpidem for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, zolpidem, and optional flavoring agent; formulation II: aqueous polar solvent, zolpidem, optionally flavoring agent, and propellant; formulation III: non-polar solvent, zolpidem, and optional flavoring agent; formulation IV: non-polar solvent, zolpidem, optional flavoring agent, and propellant; formulation V: a mixture of a polar solvent and a non-polar solvent, zolpidem, and optional flavoring agent; formulation VI: a mixture of a polar solvent and a non-polar solvent, zolpidem, optional flavoring agent, and propellant.

Claims (9)

1 - 62 . (canceled)

63 . An oral spray composition comprising

zolpidem tartarate in an amount of about 4-5% by weight of the total composition,

propylene glycol in an amount about 30-40% by weight of the total composition, and

a flavoring agent at in an amount about 0.1-0.3% by weight of the total composition.

64 . The composition of claim 63 ,

wherein the Zolpidem tartarate is present in an amount of about 4.66%,

propylene glycol is present in an amount about 35%,

and the flavoring agent is present at about 0.26%.