IP Library › Granted Patent US 12,214,198
Granted Patent B2
US 12,214,198 · App. 16/132,530 · Granted Feb 4, 2025

Systems and methods for the treatment of pain through neural fiber stimulation

Inventors: Maria E. Bennett (Beachwood, OH); Joseph W. Boggs, II (Carrboro, NC); Warren M. Gill (Chapel Hill, NC); John Chae (Strongsville, OH)
Assignee: SPR Therapeutics, Inc.
A61N1/36071A61N1/36017A61N1/36021A61N1/36057A61N1/0551
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Quick Facts
Patent No.
US 12,214,198
App. No.
16/132,530
Granted
Feb 4, 2025
Kind
B2
Abstract

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

Claims (18)

1. An electrical stimulation system comprising:

a percutaneous lead consisting of a single contact electrode, wherein the single contact electrode is configured to be inserted in-vivo a therapeutically effective distance from a target afferent nerve fiber; and

an external electrical stimulator operatively coupled with the single contact electrode, wherein the external electrical stimulator is configured to provide electrical stimulation through the single contact electrode to the target afferent nerve fiber, wherein the external electrical stimulation comprises a waveform configured to generate an action potential in the target afferent nerve fiber while avoiding generation of unwanted responses in non-target nerve fibers.

2. The electrical stimulation system of claim 1 , wherein the single contact electrode has a surface area of approximately 20 mm 2 .

3. The electrical stimulation system of claim 1 , wherein the electrical stimulation comprises a current configured to generate the action potential in the target afferent nerve fiber while avoiding generation of unwanted responses in non-target nerve fibers.

4. The electrical stimulation system of claim 1 , wherein the electrical stimulation comprises a voltage configured to generate the action potential in the target afferent nerve fiber while avoiding generation of unwanted responses in non-target nerve fibers.

5. An electrical stimulation system comprising:

a percutaneous lead consisting of a single contact electrode coupled with the percutaneous lead, wherein the single contact electrode is configured to be positioned at a therapeutically effective distance from a target Type I or Type Ib afferent nerve fiber; and

an external electrical stimulator coupled with the percutaneous lead, wherein the electrical stimulator is configured to deliver electrical stimulation through the single contact electrode to the target Type I or Type Ib afferent nerve fiber and wherein a waveform of the electrical stimulation is configured to generate an action potential in the target Type I or Type Ib afferent nerve fiber while avoiding generation of unwanted responses in non-target Type III and Type IV afferent nerve fibers to reduce a perception of pain.

6. The electrical stimulation system of claim 5 , wherein the single contact electrode has a surface area of approximately 20 mm 2 .

7. The electrical stimulation system of claim 5 , wherein a current of the electrical stimulation is configured to generate the action potential in the target Type I or Type Ib afferent nerve fiber while avoiding generation of unwanted responses in non-target Type III and Type IV afferent nerve fibers.

8. The electrical stimulation system of claim 5 , wherein a voltage of the electrical stimulation is configured to generate the action potential in the target Type I or Type Ib afferent nerve fiber while avoiding generation of unwanted responses in non-target Type III and Type IV afferent nerve fibers.

9. An electrical stimulation system comprising:

a percutaneous lead consisting of a single contact electrode, the single contact electrode configured to be inserted into a human body; and

an electrical stimulator operatively coupled with the lead, the electrical stimulator configured to deliver electrical stimulation to at least one of Type Ia and Ib target afferent nerve fibers wherein the electrical stimulation comprises a waveform configured to generate an action potential in the at least one of Type Ia and Ib target afferent nerve fibers while avoiding generation of action potentials in non-target Type III and IV nerve fibers to reduce a perception of pain by the human body.

10. The electrical stimulation system of claim 9 , wherein the electrical stimulation comprises a waveform and wherein the waveform is configured to generate the action potential in the at least one of Type Ia and Ib target afferent nerve fibers while avoiding generation of action potentials in non-target Type III and IV nerve fibers.

11. The electrical stimulation system of claim 9 , wherein the electrical stimulation comprises a current and wherein the current is configured to generate the action potential in the at least one of Type Ia and Ib target afferent nerve fibers while avoiding generation of action potentials in non-target Type III and IV nerve fibers.

12. The electrical stimulation system of claim 9 , wherein the electrical stimulation comprises a voltage and wherein the voltage is configured to generate the action potential in the at least one of Type Ia and Ib target afferent nerve fibers while avoiding generation of action potentials in non-target Type III and IV nerve fibers.

Assignments (3)
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jan 30, 2024
From: SPR THERAPEUTICS, INC.
To: SLR INVESTMENT CORP., AS AGENT
Reel/Frame 066381/0075 →
SECURITY INTEREST Recorded Jan 30, 2024
From: SPR THERAPEUTICS, INC.
To: GEMINO HEALTHCARE FINANCE, LLC
Reel/Frame 066412/0400 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 17, 2018
From: BENNETT, MARIA E.; BOGGS, JOSEPH W.; GRILL, WARREN M.; CHAE, JOHN
To: SPR THERAPEUTICS, INC.
Reel/Frame 046885/0943 →
Continuity (7)
Continuation 14336688 · Jul 21, 2014
Continuation 13309107 · Dec 1, 2011
Continuation In Part 13294875 · Nov 11, 2011
Provisional Application 61418768 · Dec 1, 2010
Provisional Application 61418801 · Dec 1, 2010
Provisional Application 61412685 · Nov 11, 2010
Related Publication 20190015663A1 · Jan 17, 2019
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