Prosthetic valve configured to fill a volume between tissue anchors with native valve tissue

1. A prosthetic valve for implantation within a native mitral valve, the prosthetic valve comprising:

an annular valve body;

a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body, wherein the arms are configured to engage an atrial portion of the native mitral valve;

a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body, wherein the ventricular anchoring legs are configured to engage a ventricular portion of the native mitral valve; and

a blood-inflatable cuff containing at least one interior volume formed between a first cuff sheet and a second cuff sheet that is open to blood flow, wherein the blood-inflatable cuff is at least partially situated between the arms and legs,

wherein the atrial anchoring arms and the ventricular anchoring legs are positioned relative to each other such that when the atrial anchoring arms and ventricular anchoring legs engage the native mitral valve, a volume bounded by the annular valve body, the atrial anchoring arms, and the ventricular anchoring legs is configured to be substantially filled with tissue such that the volume is devoid of gaps;

wherein the blood-inflatable cuff is configured to press against the tissue in the volume when inflated with blood; and

wherein a portion of at least one atrial anchoring arm and a portion of at least one ventricular anchoring leg are configured to be aligned in a common lateral plane when in a radially-expanded configuration.

2. The prosthetic valve of claim 1 , wherein the volume between the atrial anchoring arms and ventricular anchoring legs is formed between:

an outer surface of the annular valve body,

surfaces of the ventricular anchoring legs facing toward an atrium, and

surfaces of the atrial anchoring arms facing toward a ventricle.

3. The prosthetic valve of claim 1 , wherein the portions of the at least one ventricular anchoring leg and the at least one atrial anchoring arm are configured to be overlapping.

4. The prosthetic valve of claim 3 , wherein a circumference formed by the overlapping portions of the at least one ventricular anchoring leg and the at least one atrial anchoring arm forms an outer boundary of the volume.

5. The prosthetic valve of claim 1 , wherein at least one atrial anchoring arm includes:

a first portion configured to extend toward a ventricle, and

a second portion configured to extend toward an atrium.

6. The prosthetic valve of claim 5 , wherein the first portion of the at least one atrial anchoring arm is configured to form a boundary of the volume between the atrial anchoring arms and ventricular anchoring legs.

7. The prosthetic valve of claim 5 , wherein the second portion is situated radially outward from the volume between the atrial anchoring arms and ventricular anchoring legs.

8. The prosthetic valve of claim 5 , wherein the second portion is situated radially outward from the first portion.

9. The prosthetic valve of claim 5 , wherein the first portion has a flexibility that varies from a radially inner end of the first portion to a radially outer end of the first portion.

10. The prosthetic valve of claim 1 , wherein the diameter of an outer circumference defined by terminal ends of the ventricular anchoring legs is between 1.6 and 1.8 times larger than a diameter of an inner circumference of the annular valve body.

11. The prosthetic valve of claim 10 , wherein the inner circumference of the annular valve body is defined by an inner surface of the annular valve body to which prosthetic leaflets are coupled.

12. The prosthetic valve of claim 1 , wherein the atrial anchoring arms and ventricular anchoring legs are angularly offset from each other.

13. The prosthetic valve of claim 1 , wherein at least one ventricular anchoring leg includes at least one curved portion.

14. The prosthetic valve of claim 1 , wherein a radially inner-most portion of at least one atrial anchoring arm is configured to extend toward an atrium.

15. The prosthetic valve of claim 1 , wherein the entire length of at least one ventricular anchoring leg is configured to extend toward an atrium.

16. The prosthetic valve of claim 1 , wherein the annular valve body includes:

an atrial end,

a ventricular end opposite the atrial end, and

an intermediate portion extending between the atrial end and the ventricular end; and

wherein the atrial anchoring arms and ventricular anchoring legs are configured to extend from the intermediate portion.

17. The prosthetic valve of claim 1 , wherein the annular valve body includes:

an annular outer frame; and

an inner frame situated at least partially within the annular outer frame,

wherein the atrial anchoring arms extend from the inner frame and the ventricular anchoring legs extend from the annular outer frame.

18. The prosthetic valve of claim 17 , wherein the ventricular anchoring legs are configured to deflect radially outward while the atrial anchoring arms remain in a radially-contracted configuration.

19. The prosthetic valve of claim 18 , wherein the radially-contracted configuration is a delivery configuration and the radially-expanded configuration is a deployed configuration.

20. The prosthetic valve of claim 1 , wherein the volume between the atrial anchoring arms and ventricular anchoring legs is greater when the annular valve body is configured in a radially-contracted configuration than when the annular valve body is configured in the radially-expanded configuration.

21. The prosthetic valve of claim 20 , wherein the radially-contracted configuration is a delivery configuration and the radially-expanded configuration is a deployed configuration.

22. The prosthetic valve of claim 1 , wherein the volume between the atrial anchoring arms and ventricular anchoring legs of the annular valve body decreases after the annular valve body radially expands.