Topical composition and method for treating and preventing atopic dermatitis and infections related to bacteria biofilm
A nanoemulsion containing a quaternary ammonium salt with at least a twenty carbon chain is effective to prevent the growth of biofilms.
1. A topical composition comprising an oil in water nanoemulsion wherein said nanoemulsion comprises
behentrimonium chloride, wherein said behentrimonium chloride is present in an amount from about 2% to about 5% by weight of the composition,
glycerin, wherein said glycerin is present in an amount from about 5% to about 15% by weight of the composition;
a water phase; and
cetyl alcohol, wherein said cetyl alcohol is present in an amount 0.5% to about 5% by weight of the composition,
wherein said nanoemulsion comprise droplets having a Sauter diameter D[3;2] between about 52 nm to about 60 nm.
2. The topical composition according to claim 1 , wherein said composition is free of additional surfactants.
3. The topical composition according to claim 1 , wherein said nanoemulsion comprises droplets having a Sauter diameter D[3;2] of about 52 nm.
4. The topical composition according to claim 1 , wherein the topical composition comprises about 5% to about 15% by weight of water based on total weight of the topical composition.
5. The topical composition according to claim 1 , comprising about 50% to about 90% by weight of water based on total weight of the topical composition.
6. The topical composition according to claim 1 , wherein said composition is free of a preservative.
7. A method of killing or inhibiting the growth of bacteria in a biofilm comprising exposing a biofilm to the nanoemulsion according to claim 1 .
8. The method of claim 7 , wherein the bacteria in the biofilm is Staphylococcus aureus.