Granted Patent
B2
US 10,864,175 · App. 16/140,090 · Granted Dec 15, 2020
Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride
Assignee:
Tonix Pharma Holdings Limited
A61K31/135A61K9/145A61K9/1623A61K9/1688A61K9/1694A61K31/047A61K31/137A61K47/02A61K47/10A61K47/12A61K47/26A61K31/55
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Abstract
The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.
Claims (4)
1. A eutectic of Cyclobenzaprine HCl and β-mannitol comprising 75%±2% cyclobenzaprine HCl and 25%±2% β-mannitol by weight.
2. The eutectic of claim 1 , wherein the Cyclobenzaprine HCl:β-mannitol molar ratio is 1.76±0.1.
3. The eutectic of claim 1 or 2 , wherein the Cyclobenzaprine HCl is micronized Cyclobenzaprine HCl.
4. The eutectic of any one of claim 1 - 3 , wherein the eutectic melts at 143.6±3° C.
Assignments (5)
NOVATION AGREEMENT
Recorded Jul 8, 2024
From: TONIX PHARMA HOLDINGS LIMITED
To: TONIX PHARMA LIMITED
Reel/Frame 068217/0592 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 25, 2020
From: TONIX PHARMACEUTICALS, INC.
To: TONIX PHARMA HOLDINGS LIMITED
Reel/Frame 052010/0959 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 24, 2018
From: NEBULONI, MARINO; COLOMBO, PATRIZIA
To: REDOX SRL
Reel/Frame 046954/0489 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 24, 2018
From: REDOX SRL
To: TONIX PHARMACEUTICALS, INC.
Reel/Frame 046954/0510 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 24, 2018
From: TONIX PHARMACEUTICALS, INC.
To: TONIX PHARMA HOLDINGS LIMITED
Reel/Frame 046954/0517 →
Continuity (3)
Continuation
14776624
Provisional Application
61792757
· Mar 15, 2013