Compositions and therapeutic methods for the treatment of complement-associated diseases
The invention comprises methods of modulating the complement cascade in a mammal and for treating and/or preventing diseases and disorders associated with the complement pathway by administering a compound of Formula I or Formula II, such as, for example, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one or a pharmaceutically acceptable salt thereof.
1. A compound selected from:
2-{4-[2-(3,3-difluoropyrrolidin-1-yl)ethoxy]-3,5-dimethylphenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one;
methyl N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}carbamate;
and stereoisomers, tautomers, pharmaceutically acceptable salts, and hydrates thereof.
2. The compound of claim 1 , wherein the compound is 2-{4-[2-(3,3-difluoropyrrolidin-1-yl)ethoxy]-3,5-dimethylphenyl}-5,7-dimethoxy-3,4-dihydroquinazolin-4-one.
3. The compound of claim 1 , wherein the compound is methyl N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}carbamate.
4. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
5. A pharmaceutical composition comprising the compound of claim 2 and a pharmaceutically acceptable carrier.
6. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable carrier.