Systems and methods for anchoring and sealing a prosthetic heart valve

1. A method of implanting a prosthetic heart valve, comprising:

advancing a prosthetic heart valve to an implantation location within a patient's body, wherein the prosthetic heart valve is in a first radially contracted configuration and is releasably coupled to a delivery apparatus;

positioning the prosthetic heart valve within a native heart valve annulus;

expanding a frame of the prosthetic heart valve from the first radially contracted configuration to a first radially expanded configuration by actuating the delivery apparatus;

contracting the frame of the prosthetic heart valve from the first radially expanded configuration to a second radially contracted configuration by actuating the delivery apparatus;

repositioning the prosthetic heart valve within the native heart valve annulus while the frame of the prosthetic heart valve is in the second radially contracted configuration;

expanding the frame of the prosthetic heart valve from the second radially contracted configuration to a second radially expanded configuration by actuating the delivery apparatus; and

releasing the prosthetic heart valve from the delivery apparatus while the prosthetic heart valve is in the second radially expanded configuration, wherein releasing the prosthetic heart valve from the delivery apparatus results in radial expansion of a flange portion of the prosthetic heart valve, wherein the flange portion comprises a plurality of petals, wherein the delivery apparatus comprises a plurality of control wires disposed radially outwardly from the petals when the prosthetic heart valve is releasably coupled to the delivery apparatus, and wherein the petals expand radially outwardly beyond the control wires when the prosthetic heart valve is released from the delivery apparatus.

2. The method of claim 1 , wherein contracting the frame occurs while the prosthetic heart valve is disposed outside of a sheath of the delivery apparatus.

3. The method of claim 2 , wherein actuating the delivery apparatus includes moving one or more actuation wires of the delivery apparatus relative to the frame of the prosthetic heart valve.

4. The method of claim 3 , wherein the frame of the prosthetic heart valve includes one or more actuation members coupled to the frame, and wherein each of the actuation wires of the delivery apparatus is coupled to a respective actuation member of the prosthetic heart valve.

5. A method of implanting a prosthetic heart valve, comprising:

advancing a prosthetic heart valve through a patient's vasculature with a delivery apparatus such that the prosthetic heart valve is disposed in or adjacent a native heart valve;

deploying the prosthetic heart valve from a sheath of the delivery apparatus;

expanding a frame of the prosthetic heart valve from a radially contracted configuration to a radially expanded configuration, wherein the prosthetic heart valve comprises one or more flanges that are retained in an at least partially radially contracted configuration by control wires of the delivery apparatus;

contracting the frame of the prosthetic heart valve from the radially expanded configuration to an at least partially radially contracted configuration;

moving the prosthetic heart valve relative to the native heart valve annulus while the frame of the prosthetic heart valve is in the at least partially radially contracted configuration;

re-expanding the frame of the prosthetic heart valve from the at least partially radially contracted configuration to the radially expanded configuration;

releasing the prosthetic heart valve from the delivery apparatus by releasing the control wires from the prosthetic heart valve; and

after releasing the prosthetic heart valve from the control wires of the delivery apparatus, expanding the one or more flanges of the prosthetic heart valve from the at least partially radially contracted configuration to a radially expanded configuration.

6. The method of claim 5 , wherein contracting the frame occurs while the prosthetic heart valve is radially outside and axially spaced from the sheath of the delivery apparatus.

7. The method of claim 5 , wherein the one or more flanges of the prosthetic heart valve include an atrial flange having a plurality of atrial petals configured to engage native tissue on an atrial side of a native mitral valve.

8. The method of claim 7 , wherein the control wires are disposed radially outwardly from the atrial petals while the prosthetic heart valve is coupled to the delivery apparatus, and wherein the one or more control wires are configured to radially compress the atrial petals while the prosthetic heart valve is coupled to the delivery apparatus.

9. The method of claim 5 , wherein the one or more flanges of the prosthetic heart valve include a ventricular flange configured to engage native tissue on a ventricular side of a native mitral valve.

10. The method of claim 9 , wherein the control wires are disposed radially outwardly from the ventricular flange while the prosthetic heart valve is coupled to the delivery apparatus, and wherein the one or more control wires are configured to radially compress the ventricular flange while the prosthetic heart valve is coupled to the delivery apparatus.