IP Library Granted Patent US 12,174,180
Granted Patent B2
US 12,174,180 · App. 16/144,533 · Granted Dec 24, 2024

Fluid test cartridge, fluid test apparatus including the same, and method for controlling the fluid test apparatus

Inventors: Yu Kyung Tak (Seoul, KR); Sung Ha Park (Hwaseong-si, KR); Takayuki Taguchi (Osaka, JP)
Assignee: PRECISION BIOSENSOR INC.
G01N33/54346G01N21/77G01N33/5306G01N33/552G01N2021/7786G01N2021/825
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Quick Facts
Patent No.
US 12,174,180
App. No.
16/144,533
Granted
Dec 24, 2024
Kind
B2
Abstract

A fluid test cartridge, a fluid test apparatus, and a method for controlling the same. The fluid test apparatus includes a housing, and a fluid test cartridge that is accommodated in the housing. The fluid test cartridge includes at least one chamber in which a fluid sample to be tested and a drying reagent can be accommodated. The fluid test apparatus includes a light emitter configured to emit light to the at least one chamber, a light sensor, and a processor configured to detect a concentration of a first material in the fluid sample. The drying reagent includes a non-metallic particle bound to a second material that specifically binds to the first material. Tests can thus be carried out over a wider range of wavelengths, and testing errors can be reduced.

Claims (49)

1. A fluid test apparatus comprising:

a housing;

a fluid test cartridge that is accommodated in the housing, the fluid test cartridge including an array of chambers configured to accommodate a fluid sample and a drying reagent;

a light emitter configured to emit light towards the array of chambers;

a light sensor configured to receive the light incident on the array of chambers and to detect an optical property of a first material included in the fluid sample based on the received light; and

a processor capable of determining a concentration of the first material based on the optical property detected by the light sensor,

wherein the drying reagent includes a non-metallic particle bound to a second material that specifically binds to the first material,

wherein the non-metallic particle is a nano-sized particle, and the nano-sized particle is at least one element selected from the group consisting of a carbon nanoparticle, a ceramic nanoparticle, and a polymeric nanoparticle, and

wherein the non-metallic particle absorbs an entire wavelength of visible light,

wherein the array of chambers comprises a first chamber which accommodates a first drying reagent, and a second chamber which accommodates a second drying reagent, and

wherein the first drying reagent comprises a first amount of an internal standard material included in the fluid sample and the second drying reagent comprises a second amount of the internal standard material included in the fluid sample,

wherein a first concentration of the first amount of the internal standard material, and a second concentration of the second amount of the internal standard material are preset, and the preset concentrations are mapped to identification information associated with the fluid test cartridge,

wherein the second material of the first drying reagent is different from the second material of the second drying reagent such that the first drying reagent measures a first concentration of the first material, and the second drying reagent measures a second concentration of the first material different from the first concentration, and

wherein the first material is antigens, and the second material is antibodies.

2. The fluid test apparatus of claim 1 , wherein the non-metallic particle comprises at least one of a single particle or a combination of particles.

3. The fluid test apparatus of claim 1 , wherein the ceramic nanoparticle is at least one element selected from the group consisting of glass and nano-silica.

4. The fluid test apparatus of claim 1 , wherein the polymeric nanoparticle is at least one element selected from the group consisting of polymethyl methacrylate, polystyrene, cellulose, latex, hydrogel, and agarose.

5. The fluid test apparatus of claim 1 , wherein the processor is further capable of determining concentration values of the first material over a plurality of wavelength bands of light received by the light sensor.

6. A fluid test cartridge comprising:

an inlet through which a fluid sample is introduced;

a tester configured to receive the fluid sample from the inlet and to test the fluid sample, wherein the tester comprises an array of chambers that accommodates the fluid sample introduced through the inlet and a drying reagent, the drying reagent including a nonmetallic particle bound to a second material that specifically binds to a first material included in the fluid sample,

wherein the non-metallic particle is a nano-sized particle, and is at least one element selected from the group consisting of a carbon nanoparticle, a ceramic nanoparticle, and a polymeric nanoparticle, and

wherein the non-metallic particle absorbs an entire wavelength of visible light,

wherein the array of chambers comprises a first chamber which accommodates a first drying reagent, and a second chamber which accommodates a second drying reagent, and

wherein the first drying reagent comprises a first amount of an internal standard material included in the fluid sample and the second drying reagent comprises a second amount of the internal standard material included in the fluid sample,

wherein a first concentration of the first amount of the internal standard material, and a second concentration of the second amount of the internal standard material are preset, and the preset concentrations are mapped to identification information associated with the fluid test cartridge,

wherein the second material of the first drying reagent is different from the second material of the second drying reagent such that the first drying reagent measures a first concentration of the first material, and the second drying reagent measures a second concentration of the first material different from the first concentration, and

wherein the first material is antigens, and the second material is antibodies.

7. The fluid test cartridge of claim 6 , wherein the non-metallic particle comprises at least one of a single particle or a combination of particles.

8. The fluid test cartridge of claim 6 , wherein the ceramic nanoparticle is at least one element selected from the group consisting of glass and nano-silica.

9. The fluid test cartridge of claim 6 , wherein the polymeric nanoparticle is at least one element selected from the group consisting of polymethyl methacrylate, polystyrene, cellulose, latex, hydrogel, and agarose.

10. A method for controlling a fluid test apparatus, the method comprising:

Providing a fluid test apparatus comprising:

a housing;

a fluid test cartridge that is accommodated in the housing, the fluid test cartridge including an array of chambers configured to accommodate a fluid sample and a drying reagent;

a light emitter configured to emit light towards the array of chambers;

a light sensor configured to receive the light incident on the array of chambers and to detect an optical property of a first material included in the fluid sample based on the received light; and

a processor capable of determining a concentration of the first material based on the optical property detected by the light sensor,

wherein the drying reagent includes a non-metallic particle bound to a second material that specifically binds to the first material,

wherein the non-metallic particle is a nano-sized particle, and the nano-sized particle is at least one element selected from the group consisting of a carbon nanoparticle, a ceramic nanoparticle, and a polymeric nanoparticle, and wherein the non-metallic particle absorbs an entire wavelength of visible light,

wherein the array of chambers comprises a first chamber which accommodates a first drying reagent, and a second chamber which accommodates a second drying reagent, and

wherein the first drying reagent comprises a first amount of an internal standard material included in the fluid sample and the second drying reagent comprises a second amount of the internal standard material included in the fluid sample,

wherein a first concentration of the first amount of the internal standard material, and a second concentration of the second amount of the internal standard material are preset, and the preset concentrations are mapped to identification information associated with the fluid test cartridge,

wherein the second material of the first drying reagent is different from the second material of the second drying reagent such that the first drying reagent measures a first concentration of the first material, and the second drying reagent measures a second concentration of the first material different from the first concentration, and

wherein the first material is antigens, and the second material is antibodies;

mounting the fluid test cartridge in a housing of the fluid test apparatus;

reacting the fluid sample with the first drying reagent and/or the second drying reagent; and

analyzing a reaction in the fluid test cartridge by measuring an optical property of the first material with the light sensor.

11. The method for controlling the fluid test apparatus of claim 10 , wherein the analyzing comprises measuring a first optical property in the first chamber with the light sensor, and measuring a second optical property in the second chamber with the light sensor.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 12, 2022
From: SAMSUNG ELECTRONICS CO., LTD.
To: PRECISION BIOSENSOR INC.
Reel/Frame 060632/0598 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2018
From: TAK, YU KYUNG; PARK, SUNG HA; TAGUCHI, TAKAYUKI
To: SAMSUNG ELECTRONICS CO., LTD.
Reel/Frame 046998/0195 →
Priority Claims (1)
KR 10-2018-0040265 · Apr 6, 2018 · national
Continuity (1)
Related Publication 20190310247A1 · Oct 10, 2019