IP Library Granted Patent US 10,660,701
Granted Patent B2
US 10,660,701 · App. 16/147,403 · Granted May 26, 2020

Methods of removing heat from an electrode using thermal shunting

Inventors: Eric Andrew Schultheis (Sunnyvale, CA); Josef Vincent Koblish (Sunnyvale, CA); Dorin Panescu (Sunnyvale, CA)
Assignee: Epix Therapeutics, Inc.
A61B18/1492A61B5/01A61B5/0422A61B5/068A61B5/150954A61B5/6852A61B18/1206A61B2018/0016A61B2018/00023A61B2018/00029A61B2018/00083A61B2018/00101A61B2018/00351A61B2018/00357A61B2018/00577A61B2018/00642A61B2018/00672A61B2018/00678A61B2018/00702A61B2018/00714A61B2018/00761A61B2018/00797A61B2018/00815A61B2018/00821A61B2018/00839A61B2018/00875A61B2018/128A61B2018/1467A61B2217/007A61B2218/002A61B2562/046
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Quick Facts
Patent No.
US 10,660,701
App. No.
16/147,403
Granted
May 26, 2020
Kind
B2
Abstract

According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

Claims (44)

1. A method of heat removal from an electrode assembly during a tissue treatment procedure, the method comprising:

delivering energy to an electrode assembly of an ablation system, the ablation system comprising a catheter comprising a distal end, the electrode assembly positioned along the distal end of the catheter;

the catheter of the ablation system comprises a plurality of thermal shunt members along its distal end,

a first one of the plurality of thermal shunt members extends at least partially through an interior of the electrode assembly;

a second one of the plurality of thermal shunt members being disposed proximal to the first one of the plurality of thermal shunt members, a third one of the plurality of shunt members being distal to and spaced apart from the second one of the plurality of shunt members by at least a portion of the electrode assembly, the second one and the first one of the plurality of thermal shunt members being differently sized;

the catheter further comprises at least one fluid passage extending at least partially through the interior of the electrode assembly and an interior of the plurality of thermal shunt members;

delivering a fluid through the at least one fluid passage; and

transferring heat from the electrode assembly to the fluid via the plurality of thermal shunt members to reduce the likelihood of localized hot spots along the distal end of the catheter.

2. The method of claim 1 ,

wherein the plurality of thermal shunt members is configured to transfer heat while not retaining heat, and wherein the plurality of thermal shunt members comprises a thermal diffusivity greater than 1.5 cm 2 /sec;

wherein the electrode assembly comprises at least one radiofrequency electrode; and

wherein the at least one fluid passage is configured to place the electrode assembly in fluid communication with a fluid source to selectively remove heat from the electrode assembly and/or tissue of a subject located adjacent the electrode assembly.

3. The method of claim 1 , wherein the plurality of thermal shunt members is configured to transfer heat while not retaining heat, and wherein the plurality of thermal shunt members comprises a thermal diffusivity greater than 1.5 cm 2 /sec.

4. The method of claim 1 , wherein the plurality of thermal shunt members comprises a diamond or other carbon-based material.

5. The method of claim 1 , wherein the electrode assembly comprises a composite electrode, the composite electrode comprising a first electrode portion and at least a second electrode portion, wherein an electrically insulating gap is located between the first electrode portion and the at least a second electrode portion to facilitate high-resolution mapping along a targeted anatomical area.

6. The method of claim 1 , wherein the at least one fluid passage is configured to place the electrode assembly in fluid communication with a fluid source to selectively remove heat from the electrode assembly and tissue of a subject located adjacent the electrode assembly.

7. The method of claim 1 , wherein the at least one fluid passage is in direct thermal communication with plurality of thermal shunt members.

8. The method of claim 1 , wherein the at least one fluid passage comprises at least one opening, wherein the at least one opening allows fluid flowing through the at least one fluid passage to exit the catheter.

9. A method of heat removal from an electrode assembly during a tissue treatment procedure, comprising:

delivering energy to an electrode assembly of an ablation system, the electrode assembly positioned along a distal end of an elongate body;

a plurality of thermal shunt members extends at least partially through an interior of the electrode assembly, the plurality of thermal shunt members further includes a first thermal shunt member spaced from a second thermal shunt member, the second thermal shunt member being differently sized that the first thermal shunt member; a third one of the plurality of shunt members being distal to and spaced apart from the second one of the plurality of shunt members by at least a portion of the electrode assembly; and

the elongate body further comprises at least one fluid passage extending at least partially through the interior of the plurality of thermal shunt members

delivering a fluid through the at least one fluid passage; and

transferring heat from the electrode assembly to the fluid via the plurality of thermal shunt members to reduce the likelihood of localized hot spots along the distal end of the elongate body.

10. The method of claim 9 ,

wherein the at least one thermal shunt member is configured to transfer heat while not retaining heat, and wherein the at least one thermal shunt member comprises a thermal diffusivity greater than 1.5 cm 2 /sec; and

wherein the at least one fluid passage is configured to place the electrode assembly in fluid communication with a fluid source to selectively remove heat from the electrode assembly and/or tissue of a subject located adjacent the electrode assembly.

11. The method of claim 9 , wherein the plurality of thermal shunt members is configured to transfer heat while not retaining heat, and wherein the at least one thermal shunt member comprises a thermal diffusivity greater than 1.5 cm 2 /sec.

12. The method of claim 9 , wherein the plurality of thermal shunt members comprises a diamond or other carbon-based material.

13. The method of claim 9 , wherein the electrode assembly comprises a composite electrode, the composite electrode comprising a first electrode portion and at least a second electrode portion, wherein an electrically insulating gap is located between the first electrode portion and the at least a second electrode portion to facilitate high-resolution mapping along a targeted anatomical area.

14. The method of claim 9 , wherein the at least one fluid passage is in direct thermal communication with the plurality of thermal shunt members.

15. A method of heat removal from an ablation member during a tissue treatment procedure, comprising:

delivering energy to an ablation member of an ablation system, the ablation member positioned along a distal end of an elongate body;

a plurality of thermal shunt members extends at least partially through an interior of the ablation member; and

at least one fluid passage extends at least partially through an interior of the plurality of thermal shunt members, the plurality of thermal shunt members further includes a first thermal shunt member spaced from a second thermal shunt member, at least a portion of the ablation member being disposed between the first and second thermal shunt members, the second thermal shunt member being differently sized that the first thermal shunt member, a third one of the plurality of thermal shunt members being differently sized than first thermal shunt member and the second thermal shunt member;

delivering a fluid through the at least one fluid passage; and

transferring heat from the electrode assembly to the fluid via the plurality of thermal shunt members.

16. The method of claim 15 ,

wherein the plurality of thermal shunt members is configured to transfer heat while not retaining heat, and wherein the plurality of thermal shunt members comprises a thermal diffusivity greater than 1.5 cm 2 /sec; and

wherein the at least one fluid passage is configured to place the ablation member in fluid communication with a fluid source to selectively remove heat from the ablation member and tissue of a subject located adjacent the ablation member.

17. The method of claim 15 , wherein the plurality of thermal shunt members is configured to transfer heat while not retaining heat, and wherein plurality of thermal shunt members comprises a thermal diffusivity greater than 1.5 cm 2 /sec.

18. The method of claim 15 , wherein the plurality of thermal shunt members comprises a diamond or other carbon-based material.

19. The method of claim 15 , wherein the ablation member comprises a composite electrode, the composite electrode comprising a first electrode portion and at least a second electrode portion, wherein an electrically insulating gap is located between the first electrode portion and the at least a second electrode portion to facilitate high-resolution mapping along a targeted anatomical area.

20. The method of claim 15 , wherein the at least one fluid passage is in direct thermal communication with the plurality of thermal shunt members.

Assignments (2)
CHANGE OF NAME Recorded Oct 17, 2018
From: ADVANCED CARDIAC THERAPEUTICS, INC.
To: EPIX THERAPEUTICS, INC.
Reel/Frame 047245/0509 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 11, 2018
From: PANESCU, DORIN; KOBLISH, JOSEF VINCENT; SCHULTHEIS, ERIC ANDREW
To: ADVANCED CARDIAC THERAPEUTICS, INC.
Reel/Frame 047138/0795 →
Continuity (10)
Continuation 15336648 · Oct 27, 2016
Continuation 15214376 · Jul 19, 2016
Continuation PCTUS2015061419 · Nov 18, 2015
Provisional Application 62081710 · Nov 19, 2014
Provisional Application 62094892 · Dec 19, 2014
Provisional Application 62135046 · Mar 18, 2015
Provisional Application 62135025 · Mar 18, 2015
Provisional Application 62138338 · Mar 25, 2015
Provisional Application 62211539 · Aug 28, 2015
Related Publication 20190029753A1 · Jan 31, 2019