Food and beverage compositions infused with lipophilic active agents and methods of use thereof
Aspects described herein relate to food and beverage compositions infused with lipophilic active agents and methods of use for the treatment of a variety of disorders. More particularly, aspects described herein relate to food and beverage compositions infused with lipophilic active agents such as cannabinoids, nicotine, nonsteroidal anti-inflammatories (NSAIDs), and vitamins, that provide enhanced bioavailability of the lipophilic active agents in a subject, and that mask unpleasant tastes of lipophilic active agents.
1. Lipophilic active agent infused tea leaves, coffee beans, or cocoa powder comprising:
(a) a therapeutically effective amount of a cannabinoid and at least one additional lipophilic active agent;
(b) a bioavailability enhancing agent comprising an edible oil comprising long chain fatty acids, wherein the bioavailability of the cannabinoid in a subject is at least 1.5 times greater than the bioavailability of the cannabinoid in the subject in the absence of the bioavailability enhancing agent; and
(c) tea leaves, coffee beans, or cocoa powder;
wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are obtainable by the steps of:
(i) contacting the tea leaves, coffee beans, or cocoa powder with an oil comprising the cannabinoid, the at least one additional lipophilic active agent, and the bioavailability enhancing agent; and
(ii) dehydrating the tea leaves, coffee beans, or cocoa powder, thereby producing the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder;
wherein the additional lipophilic active agent is selected from the group consisting of nicotine, a non-steroidal anti-inflammatory drug (NSAID), and a vitamin.
2. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability of the cannabinoid in a subject is at least 3 times greater than the bioavailability of the cannabinoid in the subject in the absence of the bioavailability enhancing agent.
3. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability of the cannabinoid in a subject is at least 4.5 times greater than the bioavailability of the cannabinoid in the subject in the absence of the bioavailability enhancing agent.
4. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability enhancing agent is free of omega-6 fatty acids.
5. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the cannabinoid is a psychoactive cannabinoid.
6. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the cannabinoid is a nonpsychoactive cannabinoid.
7. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability enhancing agent is a protective colloid, an edible oil or fat, and a cannabinoid taste masking agent.
8. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability enhancing agent is nonfat dry milk.
9. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 8 , further wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are lyophilized.
10. A lipophilic active agent infused beverage product obtainable by the steps of:
(a) contacting tea leaves, coffee beans, or cocoa powder with an oil comprising a cannabinoid, an additional lipophilic active agent, and a bioavailability enhancing agent;
(b) dehydrating the coffee beans or cocoa powder, thereby producing lipophilic active agent infused coffee beans or cocoa powder; and
(c) steeping the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder in a liquid, thereby producing the lipophilic active agent infused beverage product;
wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder comprise:
(i) a therapeutically effective amount of the cannabinoid and the additional lipophilic active agent;
(ii) a bioavailability enhancing agent comprising an edible oil comprising long chain fatty acids, wherein the bioavailability of the cannabinoid in a subject is at least 1.5 times greater than the bioavailability of the cannabinoid in the subject in the absence of the bioavailability enhancing agent; and
(iii) coffee beans or cocoa powder;
wherein the additional lipophilic active agent is selected from the group consisting of nicotine, a non-steroidal anti-inflammatory drug (NSAID), and a vitamin.
11. The lipophilic active agent infused beverage product of claim 10 , wherein the bioavailability of the cannabinoid in a subject is at least 3 times greater than the bioavailability of the cannabinoid in the subject in the absence of the bioavailability enhancing agent.
12. The lipophilic active agent infused beverage product of claim 10 , wherein the bioavailability of the cannabinoid in a subject is at least 4.5 times greater than the bioavailability of the cannabinoid in the subject in the absence of the bioavailability enhancing agent.
13. The lipophilic active agent infused beverage product of claim 10 , wherein the bioavailability enhancing agent is free of omega-6 fatty acids.
14. The lipophilic active agent infused beverage product of claim 10 , wherein the cannabinoid is a psychoactive cannabinoid.
15. The lipophilic active agent infused beverage product of claim 10 , wherein the cannabinoid is a nonpsychoactive cannabinoid.
16. The lipophilic active agent infused beverage product of claim 10 , wherein the bioavailability enhancing agent is a protective colloid, an edible oil or fat, and a cannabinoid taste masking agent.
17. The lipophilic active agent infused beverage product of claim 10 , wherein the bioavailability enhancing agent is nonfat dry milk.
18. The lipophilic active agent infused beverage product of claim 10 , further wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are lyophilized.