Fluorine- and/or deuterium-containing compounds for treating non-small cell lung cancer and related diseases
Novel fluoride and/or deuterium-containing chemical, compounds useful for treating cancer or a related disease or disorder thereof, and pharmaceutical compositions and methods of preparation and use thereof.
1. A compound of the following Formula (V) or a pharmaceutically acceptable salt or ester thereof:
2. A compound of the following Formula (IX) or a pharmaceutically acceptable salt or ester thereof:
3. A compound of the following Formula (I):
wherein each of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is independently selected from the group consisting of H, F and D, and at least one of R 1 , R 2 , R 3 , R 4 , R 5 or R 6 is F, and
wherein the compound is in the form of a mesylate salt.
4. A pharmaceutical composition comprising the compound of claim 3 , and a pharmaceutically acceptable excipient, carrier, or diluent.
5. A unit dosage form comprising the pharmaceutical composition of claim 4 .
6. The compound of claim 1 , wherein the compound is in the form of a mesylate salt.
7. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt or ester thereof, and a pharmaceutically acceptable excipient, carrier, or diluent.
8. A unit dosage form comprising the pharmaceutical composition of claim 7 .
9. The compound of claim 2 , wherein the compound is in the form of a mesylate salt.
10. A pharmaceutical composition comprising the compound of claim 2 , or a pharmaceutically acceptable salt or ester thereof, and a pharmaceutically acceptable excipient, carrier, or diluent.
11. A unit dosage form comprising the pharmaceutical composition of claim 10 .
12. A pharmaceutical composition comprising the compound of claim 6 , and a pharmaceutically acceptable excipient, carrier, or diluent.
13. A unit dosage form comprising the pharmaceutical composition of claim 12 .
14. A pharmaceutical composition comprising the compound of claim 9 , and a pharmaceutically acceptable excipient, carrier, or diluent.
15. A unit dosage form comprising the pharmaceutical composition of claim 14 .