Tyrosine kinase inhibitors
Disclosed are imidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, Y and Z are as described herein. In certain embodiments, a compound disclosed herein inhibits a cellular TAM receptor, and can be used to treat disease mediated by or involving the TAM receptor family.
1. A compound having the structure formula
or a pharmaceutically acceptable salt, or N-oxide thereof, or a solvate or hydrate thereof.
2. A pharmaceutical composition comprising a pharmaceutically acceptable diluent, carrier, or excipient and a compound according to claim 1 .
3. A method of inhibiting a cellular TAM receptor, the method comprising contacting a cell comprising a TAM receptor with a compound according to claim 1 , or a composition of claim 2 .
4. The method of claim 3 , wherein the TAM receptor is a Tyro receptor, an Axl receptor, or a Mer receptor.
5. A method for treating a disease or condition mediated by or involving the TAM receptor family in a subject in need thereof, comprising administering an effective TAM receptor inhibiting amount of a compound of claim 1 , or a composition of claim 2 , wherein the disease or condition is a hematological neoplasm.
6. The method of claim 5 , wherein the hematological neoplasms is acute myeloid leukemia AML.