Bioinformatic processing systems and methods
The present disclosure relates to systems and methods for facilitating trusted handling of genomic and/or other bioinformatic information. Certain embodiments may facilitate policy-based governance of access to and/or use of bioinformatic information, improved interaction with and/or use of distributed bioinformatic information, parallelization of various processes involving bioinformatic information, and/or reduced user involvement in bioinformatic workflow processes, and/or the like. Further embodiments may provide for memoization processes that may persistently store final and/or intermediate results of computations performed using genomic data for use in connection with future computations.
1. A method for performing trusted computations on genomic data performed by a system comprising a processor and a non-transitory computer-readable storage medium storing instructions that, when executed by the processor, cause the system to perform the method, the method comprising:
receiving a request relating to at least one computation using a plurality of genomic datasets, the request comprising identification information relating to a plurality of subjects and requesting to identify a particular genomic feature in one or more of the plurality of genomic data sets;
identifying, based on the identification information relating to the plurality of subjects, first anonymized identification information associated with at least a first subject of the plurality of subjects and second anonymized identification information associated with at least a second subject of the plurality of subjects, wherein identifying the first anonymized identification information and the second anonymized identification information is performed by a third program and executed in a first processing domain that does not have access to the plurality of genomic datasets;
communicating the first anonymized identification information to a first program configured to perform at least a first portion of the at least one computation and the second anonymized identification information to a second program configured to perform at least a second portion of the at least one computation;
generating, by the first program, a first result based at least a first genomic dataset of the plurality of genomic datasets associated with the first anonymized identification information;
generating, by the second program, a second result based at least a second genomic dataset of the plurality of genomic datasets associated with the second anonymized identification information; and
generating a response to the at least one computation based, at least in part, on the first result and the second result.
2. The method of claim 1 , wherein receiving the request relating to the at least one computation using a plurality genomic datasets comprises receiving the request from a requesting system and the method further comprises transmitting the response to the requesting system.
3. The method of claim 2 , wherein the first anonymized identification information and the second anonymized identification information is not exposed to the requesting system.
4. The method of claim 2 , wherein the plurality of genomic datasets are not exposed to the requesting system.
5. The method of claim 1 , wherein the request comprises a request to identify a particular genomic feature in genomic data of the plurality of genomic data sets associated with the plurality of subjects.
6. The method of claim 5 , wherein the particular genomic feature comprises a genetic variant.
7. The method of claim 6 , wherein the particular genomic feature comprises a carrier status.
8. The method of claim 1 , wherein generating the response to the at least one computation is performed by a fourth program.
9. The method of claim 8 , wherein at least one of the first program, the second program, the third program, and the fourth program is executed in a processing domain that is different than a processing domain of the other programs.
10. The method of claim 8 , wherein each of the first, program, the second program, the third program, and the forth program are executed in different processing domains.
11. The method of claim 1 , wherein identifying the first anonymized identification information and the second anonymized identification information comprises accessing a phenotypical data set.
12. The method of claim 1 , wherein the phenotypical data set associates identification information with anonymized identification information.
13. The method of claim 1 , wherein the first anonymized identification information and the second anonymized identification information comprise randomly generated identifiers.
14. The method of claim 1 , wherein the plurality of genomic datasets comprises human genomic data.
15. The method of claim 1 , wherein the request comprises authentication information.
16. The method of claim 1 , wherein the request comprises a cohort selection associated with the plurality of genomic datasets.
17. The method of claim 1 , wherein the request comprises instruction information associated with the at least one computation.