GLYCOLS AS PATHOGEN INACTIVATING AGENTS
The disclosure relates to uses, methods and compositions for the inactivation of pathogens in biological compositions, using a glycol as a pathogen inactivating agent.
1 . (canceled)
2 . (canceled)
3 . A method for inactivating a pathogen in a biological composition, said method comprising contacting said biological composition with a glycol to inactivate the pathogen.
4 . The method of claim 3 , wherein said glycol is propylene glycol.
5 . The method of claim 3 , wherein said biological composition is a blood composition or a milk composition.
6 . The method of claim 3 , wherein said pathogen is selected from the group consisting of viruses, bacteria, fungi, protozoa, parasites, and prions.
7 . The method of claim 6 , wherein said virus is selected from the group consisting of X-MuLV, PRV, BVDV and TGEV virus.
8 . The method of claim 3 , wherein said method results in a pathogen elimination equal or greater than 4 Log 10 TCID (Tissue Culture Infective Dose), wherein the TCID is according to the methods of Kärber and/or Spearman-Kärber.
9 . The method of claim 3 , wherein the concentration of glycol after the contacting step is between 40 and 50% (v/v) of the biological composition.
10 . The method of claim 3 , wherein said method is performed at a temperature between 15 and 25° C.
11 . The method of claim 3 , wherein said method is performed at a pH between 7.0 and 8.0.
12 . A biological composition comprising glycol, wherein the biological composition is obtained by the method of claim 3 .
13 . The biological composition of claim 12 , wherein said glycol is at a concentration between 40 and 50% (v/v).
14 . The biological composition of claim 12 , wherein said glycol is propylene glycol.